Is Tezepelumab effective in managing severe asthma?

Question

Hello doctor,

I have been dealing with severe asthma for years and have used multiple inhalers and oral steroids. My doctor recently suggested trying Tezspire, but I am unsure how it compares to other biologics like Xolair or Dupixent. What makes Tezspire different from other biologics used for asthma? Does it target a different pathway, and is it more effective for people who do not respond well to other treatments?

Additionally, how soon can I expect to see results after starting Tezspire? I am really hoping to reduce my dependence on steroids and finally get my asthma under control. Any insight would be greatly appreciated.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your situation.

Tezspire (Tezepelumab) works differently from other biologics like Xolair (Omalizumab) and Dupixent (Dupilumab) by targeting thymic stromal lymphopoietin (TSLP), a key molecule in the inflammatory process of asthma. This broader mechanism can help reduce asthma exacerbations and improve breathing, making it potentially more effective for people who have not responded well to other treatments.

Many patients start seeing improvements within a few weeks to a few months of starting Tezepelumab. It can also help reduce the need for oral steroids, which is beneficial given their side effects. Common side effects include sore throat, joint pain, and back pain, but serious side effects are rare.

Please book a consultation with me if you would like more detailed information on any of these points, or if you have other questions.

Thank you for using iCliniq. Have a great day!