Is Tezepelumab safe for a person with liver cirrhosis?

Question

Hello doctor,

I have had severe, uncontrolled asthma for years, and it is affecting my quality of life. I read that Tezepelumab can help reduce asthma attacks and improve breathing, and I am very interested in trying it.

However, I was diagnosed with liver cirrhosis last year, and I am worried about whether this medication could harm my liver. Since Tezepelumab is a biologic, I am not sure how it is processed in the body or if it could make my liver condition worse or interact with my current medications.

Is Tezepelumab safe for someone with cirrhosis? Are there any special precautions or monitoring I would need? I want better asthma control, but I also want to protect my liver. What are my options, and would this treatment be recommended for someone in my situation?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

Tezepelumab is a biologic medicine that works by blocking TSLP (thymic stromal lymphopoietin), a key trigger for all types of asthma and allergic reactions. Unlike some other drugs, Tezepelumab is not processed by the liver; the immune system handles it. This makes it generally safer for people with liver disease.

However, there is not much data on how Tezepelumab affects people with liver cirrhosis, because they were not included in clinical trials.

Before starting Tezepelumab, people with liver disease should get liver function tests (LFTs) and closely monitor their symptoms. Tezepelumab does not weaken the immune system, but cirrhosis can increase the risk of infections, so regular monitoring is important.

I recommend Tezepelumab to you, but only under medical supervision. It can help improve your breathing and reduce inflammation in your airways.

I hope you are satisfied with my answer. For further queries, you can consult me at iCliniq.

Thank you.