Can Tezepelumab cause vocal cord issues at 60?

Question

Hello doctor,

I am 60 and was recently prescribed Tezspire for severe eosinophilic asthma. I also take a PPI for GERD and occasionally experience hoarseness after using inhalers. Is there any risk of Tezspire worsening reflux or vocal cord issues? Should I adjust the timing of my doses in relation to my reflux medication, or should I use a spacer, even though it is not an inhaler?

Please advise.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concerns.

Tezspire (Tezepelumab) is a biologic injection used to treat severe eosinophilic asthma. It primarily works by targeting inflammation and preventing asthma exacerbations. Tezspire does not directly affect the vocal cords, throat, or esophagus, and therefore does not cause hoarseness of voice or GERD (gastroesophageal reflux disease). Corticosteroids, on the other hand, can irritate the vocal cords and throat, potentially leading to hoarseness. Hoarseness can also result from GERD, where acid reflux irritates the vocal cords.

Advice:

Since Tezspire is an injectable medication and not an inhaler, there is no need to use a spacer with it. If you are using corticosteroid inhalers, a spacer should be used to reduce steroid exposure to the throat and vocal cords. Additionally, it is important to rinse your mouth after using inhalers to prevent throat irritation.
There is no need to adjust the timing of your PPI (proton pump inhibitor) dose in relation to Tezspire or other medications, as their methods of administration are completely different, and no interactions have been noted.

I hope this addresses your questions adequately.

Thanks and regards.