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Can ulcerative colitis lead to fertility issues?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am a 28-year-old woman who was diagnosed with ulcerative colitis last year after experiencing months of bloody stools and stomach pain. I am currently taking Mesalamine, but I still have flare-ups during periods of stress. I want to know:

  • If diet truly affects the condition. Should I avoid dairy or spicy foods entirely?

  • Can this disease affect fertility or pregnancy?

  • I am concerned about long-term complications, such as colon cancer. How often should I have colonoscopies to stay safe?

Please help.

Hi,

Welcome to icliniq.com.

I completely understand your concern and how challenging it can be to manage ulcerative colitis (a chronic inflammatory bowel disease that causes inflammation and ulcers in the large intestine), especially when flare-ups still occur despite taking medication. Mesalamine (an anti-inflammatory medication used to reduce colon inflammation) helps control the disease, but symptoms can still be influenced by stress, diet, and lifestyle factors.

Diet plays an important role, although it varies from person to person. There is no strict universal diet for ulcerative colitis, but many patients find that certain foods, such as spicy dishes, high-fat meals, caffeine, and alcohol, can worsen symptoms. Dairy products may also cause discomfort, particularly if lactose intolerance (difficulty digesting lactose, a sugar in milk and dairy) is present. Limiting or avoiding these foods during flare-ups may help. Eating smaller, more frequent meals, staying well-hydrated, and choosing easily digestible foods during active disease phases can also be beneficial.

Managing stress through relaxation techniques, light exercise, or yoga is important, as emotional stress can trigger or worsen symptoms.

Regarding fertility and pregnancy, ulcerative colitis usually does not reduce fertility, and most women with well-controlled disease can have healthy pregnancies. It is ideal to plan conception during a period of remission (a phase when the disease is inactive), as active inflammation during pregnancy can increase the risk of complications. Some medications may need adjustment before or during pregnancy, so coordination with your gastroenterologist (a doctor specializing in digestive system disorders) and obstetrician (a doctor specializing in pregnancy and childbirth) is important.

Long-term, people with ulcerative colitis have a slightly increased risk of colon cancer (a type of cancer affecting the large intestine), particularly if inflammation has been present for many years. To monitor this, regular colonoscopy screenings (a procedure in which a flexible tube with a camera is used to examine the colon and detect abnormalities) are recommended, usually starting 8 to 10 years after diagnosis and repeated every one or two years depending on your doctor’s advice.

With consistent medical care, a healthy lifestyle, and stress management, many people with ulcerative colitis lead full and active lives, keeping flare-ups under control and reducing long-term risks.

I hope this helps.

Kindly revert so I can assist you further.

Thank you.

Answered byDr. Ashraf Ghani

Medically reviewed byiCliniq medical review team

Published At January 1, 2026
Reviewed AtJanuary 2, 2026

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