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Is a prostate biopsy to detect cancer safe?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

During my routine checkup, my PSA was 2.8 ng/mL, and the digital rectal exam revealed an asymmetric prostate with a firm nodule on the right side. Although I am relatively young, my urologist is recommending a biopsy. Two of my uncles had prostate cancer. I stay active, maintain a healthy weight, and have no urinary symptoms. What are the risks and benefits of having a biopsy at this stage? Should I consider getting a second opinion? Please help.

Thank you.

Answered by Dr. Mona Kamal

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

The normal range for PSA (prostate-specific antigen) levels is generally considered to be between 2.5 and 4 ng/mL (nanograms per milliliter).

Although your PSA level falls within the normal range, I agree with your doctor's recommendation for further investigation due to two key factors:

  1. The presence of a prostatic nodule (lump or abnormal growth), even if it is painless.

  2. A positive family history of prostate cancer.

In 35 percent of cases, a prostatic nodule is benign; however, in 65 percent of cases, it may be cancerous. Given this, additional tests are warranted to ensure accurate diagnosis and management.

Magnetic resonance imaging (MRI) is generally considered more accurate than a biopsy (a medical procedure where a small sample of tissue is taken from the body to be examined under a microscope) in detecting prostate cancer, as a biopsy can miss cancer in approximately 20 percent of cases.

I hope this helps.

Kindly revert so I can assist you further.

Thank you.

Answered by Dr. Mona Kamal
Medically reviewed by iCliniq medical review team
Published At January 20, 2025
Reviewed At January 6, 2026

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

Master in Pathology

Professional Bio:

Dr. Mona Kamal is a highly experienced pathologist and general practitioner with over 41 years of clinical expertise. She earned her Bachelor of Medicine, Bachelor of Surgery (M.B.Ch.B.) degree in 1982 and a Master’s degree in Pathology in 1989, both from Alexandria University, Egypt. Throughout her extensive career, Dr. Kamal has consulted with over 200 patients, demonstrating a strong commitment to accurate diagnostics and comprehensive patient care. She currently practices at Shifa Lab in Alexandria, where she applies her deep knowledge of pathology alongside general medicine to provide precise and compassionate healthcare services.

This doctor is not available for online consultations on the platform anymore.

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