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How to manage hormonal therapy side effects in the elderly?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

My 66-year-old uncle has been undergoing hormone therapy for prostate cancer for the past six months. Lately, he has been experiencing significant weakness, weight gain, and mood swings. Are these common side effects of hormone therapy, and what strategies or treatments could help manage them? He hesitates to bring this up with his doctor, but it affects his quality of life. I would appreciate any advice on addressing this with him or his healthcare provider.

Kindly help.

Answered by Dr. Ali Osman

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Prostate cancer occurs when abnormal cells grow in the prostate gland. These cells can form tumors, which may be either benign (non-cancerous), such as benign prostatic hyperplasia (BPH), which is not life-threatening and does not spread, or malignant (cancerous), where growths can spread to nearby tissues like the bladder or rectum or to other parts of the body (metastasis). Cancerous tumors may grow back even after removal.

Treatment options include the following:

  1. Active surveillance: This is recommended for small, slow-growing cancers. Regular monitoring is done through PSA (prostate-specific antigen) tests, biopsies, and possibly MRI (magnetic resonance imaging). This approach helps preserve quality of life by delaying or avoiding the side effects of more aggressive treatments. If the cancer progresses, definitive treatments like surgery or radiation may be considered.
  2. Watchful waiting: This is a less intensive approach, often used for older men or those with other health conditions. It involves less frequent monitoring but carries the risk that the cancer could grow or spread between visits.

Definitive treatments:

  1. Surgery (radical prostatectomy): This involves the removal of the prostate and nearby tissues, often including pelvic lymph nodes. While effective, it comes with risks of complications, such as urinary or sexual dysfunction.
  2. Radiation therapy: This targets and destroys cancer cells but may also cause side effects.

I recommend following your doctor’s treatment plan and attending all follow-up tests. These will help monitor the cancer and detect any signs of progression early, ensuring timely intervention if needed.

Revert with the answer to assist further.

Thank you and take care.

Answered byDr. Ali Osman

Medically reviewed byiCliniq medical review team

Published At January 2, 2025
Reviewed AtSeptember 24, 2025

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Ali Osman
Dr. Ali Osman

Obstetrics and Gynecology

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