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Is it safe to use medroxyprogesterone injection long-term?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I have been using Depo-Provera for over 10 years. I am female, with a height of 5'2'' and a weight of 132.2 lbs.

Please help.

Thank you.

Hello,

Welcome to icliniq.com.

I understand your concern.

I am very sorry about your medical condition, and I am glad that you are paying attention to changes in your body system. But do not worry, I am here to take care of you. Thanks for sharing that. Here is a brief overview based on your long-term use of Depo-Provera (Medroxyprogesterone acetate) and your physical stats (female, 5 feet 2 inches), 132.2 lbs, using it for over 10 years.:

Long-term Depo-Provera use:

  • Bone Health: Depo-Provera is known to reduce bone mineral density (BMD) over time. This is especially important with use beyond two years.

  • After 10 years, there is an increased risk of osteopenia or osteoporosis.

  • A DEXA (dual energy X-ray absorptiometry) scan (bone density test) is recommended if you have not had one recently.

  • Ensure adequate calcium and vitamin D intake. Consider supplementation if needed.

Menstrual cycle changes:

  • Many women on Depo-Provera stop having periods, which is normal.

  • If your periods have not returned even after stopping them (if you plan to), it may take up to 18 months for fertility to resume.

  • So if the Depot Provera is not good enough for you, possibly due to side effects, please change to an IUCD (intrauterine contraceptive device).

I hope this helps.

Please follow up if you have any further concerns.

Thank you.

Medically reviewed byiCliniq medical review team

Published At October 11, 2025
Reviewed AtOctober 22, 2025

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