Do women with lupus need pneumococcal vaccines?

Question

Hello doctor,

I have been diagnosed with lupus and am currently undergoing treatment with immunosuppressive medications. During our last consultation, you mentioned the importance of vaccinations, but I neglected to inquire further.

Could you please provide guidance on whether women with autoimmune diseases like mine should be particularly concerned about pneumococcal infections? Additionally, I would appreciate information on the recommended frequency for pneumococcal vaccinations and any risks that might be specific to women in my condition.

Please help.

Answer 1

Hi,

Welcome to icliniq.com.

Women diagnosed with autoimmune conditions such as lupus (a chronic autoimmune condition in which the immune system mistakenly targets your tissues and organs). This leads to inflammation that may affect the joints, skin, kidneys, heart, lungs, brain, and blood vessels.

Particularly, those undergoing immunosuppressive therapy face an elevated risk of pneumococcal infections, including pneumonia (an infection that causes inflammation in the lungs), meningitis (inflammation of the meninges, the protective membranes surrounding the brain and spinal cord), and bloodstream infections (infection occurs when bacteria or fungi enter the bloodstream, an environment meant to be sterile). This heightened vulnerability stems from both the underlying disease and the immunosuppressing effects of certain medications.

Recommended pneumococcal vaccinations:

PCV20 (Prevnar 20): A single-dose vaccine offering protection against 20 pneumococcal serotypes.
PCV15 (Prevnar 15) followed by PPSV23: An alternative regimen where PCV15 is administered first, followed by PPSV23 at least one year later. In individuals with immunocompromising conditions, a minimum interval of eight weeks between the two vaccines may be considered to expedite protection.

Revaccination considerations:

For those who received pneumococcal vaccination before initiating immunosuppressive therapy, a repeat dose may be necessary three to five years later, contingent upon individual immune status and medical guidance.

Vaccination during pregnancy and breastfeeding:

Pneumococcal vaccines are generally deemed safe during pregnancy and breastfeeding. However, optimal timing is crucial. If feasible, it is advisable to complete vaccination before pregnancy, as immunosuppressive treatments can complicate infections during this period.

I hope this helps.

Kindly revert if there is any query.

Thank you.