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Can azelaic and glycolic acid cream be used in pregnancy?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

Can I use 10% Azelaic cream and 6% glycolic cream on alternate nights during pregnancy to reduce acne and black spots?

Kindly help.

Hello,

Welcome to icliniq.com.

I can understand your concern. When it comes to using skincare products like Azelaic acid and Glycolic acid during pregnancy, it is important to be cautious, as some ingredients can potentially be harmful to the developing baby. Azelaic acid is generally considered safe to use during pregnancy. It is a topical treatment often used for acne and to lighten hyperpigmentation, such as dark spots. Azelaic acid has low systemic absorption, meaning only a small amount enters the bloodstream, making it a safer option during pregnancy. Azelaic acid 10 percent is commonly used for treating acne and skin discoloration, and it is often considered a good alternative to stronger acne treatments, which may be harmful during pregnancy.

Glycolic acid is an alpha-hydroxy acid (AHA) used for exfoliating and brightening the skin. It is used to treat acne and dark spots, but strong AHAs like glycolic acid are less studied in pregnancy. Generally, glycolic acid six percent (a moderate strength) is considered low risk for topical use during pregnancy, as long as it is applied in moderation. However, because AHAs can be absorbed through the skin, it is advisable to use them sparingly and with caution, especially during the first trimester when the baby’s development is most sensitive.

If you want to alternate these two products, it is probably safe to do so, as long as you use moderate amounts and apply them on alternate nights. 10 % of Azelaic acid can be used safely during pregnancy to reduce acne and pigmentation, while six percent of glycolic acid is also likely safe in small amounts but should be used with caution due to the potential for absorption.

Key recommendations include starting slowly when introducing new products during pregnancy, for example, starting with Azelaic acid for a few days and then introducing glycolic acid every other night to allow your skin to adjust. Before using these products regularly, it’s important to patch-test on a small area of skin to ensure no irritation or sensitivity. Pregnancy hormones can make skin more sensitive, so monitor for any redness, irritation, or stinging, and reduce usage if these occur. Avoid over-exfoliating, as using too many active ingredients (like AHAs and acids) can lead to irritation or increased skin sensitivity, making alternating every other night a good strategy.

Other important notes include consulting your doctor before using any active skincare treatments during pregnancy, as your healthcare provider or dermatologist can offer personalized advice based on your skin type, pregnancy stage, and overall health. Additionally, both Azelaic acid and glycolic acid can make your skin more sensitive to the sun, so be sure to use a broad-spectrum sunscreen with at least SPF 30 every day, especially when using these treatments. In conclusion, using Azelaic acid at ten percent and glycolic acid at six percent on alternating nights during pregnancy should generally be safe, but it is always a good idea to check with your healthcare provider first.

I hope this helps.

Thank you.

Medically reviewed byiCliniq medical review team

Published At May 29, 2025
Reviewed AtJune 9, 2025

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