Do menstrual cycles trigger hereditary angioedema attacks?

Question

Hello doctor,

My boyfriend’s girlfriend has hereditary angioedema, and I overheard her say she gets unpredictable swelling attacks around her period or during stress. She mentioned avoiding estrogen-based birth control. Are there cycle-related triggers for hereditary angioedema in women? What are the best prevention options for women with hereditary angioedema, especially around menses?

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and understood your concern.

Hereditary angioedema (HAE) can indeed be influenced by hormonal changes, including those related to the menstrual cycle. Estrogen can exacerbate HAE symptoms, which is why estrogen-based birth control is often avoided. Stress is another common trigger for HAE attacks.

Cycle-related triggers for HAE in women can include:

Hormonal fluctuations during the menstrual cycle.
Use of estrogen-containing medications.
Stress and emotional changes.

To prevent HAE attacks, especially around menses, the following options can be considered:

Avoiding estrogen-based medications: Opt for progesterone-only contraceptives or non-hormonal methods.
Prophylactic medication: Medications like C1 inhibitor concentrates, Icatibant, or Ecallantide can be used to prevent attacks.
Stress management: Techniques such as mindfulness, yoga, and counseling can help reduce stress levels.
Regular monitoring: Keeping track of symptoms and triggers can help in managing and preventing attacks.

I hope this helps.

Kindly follow up if you have more doubts.

Thank you.