Can Lanadelumab help in managing acute HAE attacks?
Patient's Query
Hello doctor,
I am 36 years old and was recently diagnosed with HAE (hereditary angioedema) after years of misdiagnosed swellings. I have started Lanadelumab, but I am anxious about how to handle acute attacks.
Should I carry on-demand rescue therapy like Firazyr everywhere?
Can routine vaccinations or dental visits trigger an episode?
If I want to become pregnant, is Lanadelumab safe, or should I switch therapies?
Also, how do I talk to ER (emergency room) doctors who are not familiar with HAE?
Should I need to carry out some sort of emergency plan?
Please suggest.
Thank you.
Hello,
Welcome to icliniq.com.
I have read your query and can understand your concern.
Yes, carrying on-demand rescue therapy like Firazyr (Icatibant) with you at all times is strongly recommended for individuals with hereditary angioedema (HAE). Guidelines advise having enough treatment for at least two attacks that is readily available. This is because HAE attacks can be unpredictable and require prompt treatment. Firazyr is a portable, self-administered subcutaneous injection that can be used to treat acute HAE attacks. Both routine vaccinations and dental visits can potentially trigger hereditary angioedema (HAE) attacks.
Dental procedures and oral surgery, including routine treatments, are known to be physical stress triggers, and physical stress can lead to HAE attacks. Vaccinations, while typically not directly associated with HAE, can sometimes cause systemic reactions that may trigger an attack, particularly if there is an underlying infection or inflammatory response. Lanadelumab can cross the placenta during the third trimester of pregnancy, causing harmful effects on the fetus. Few doctors are familiar with HAE, but specialists like allergists or immunologists can help. Whether you are seeking a diagnosis or looking to manage HAE, the right doctor can make all the difference.
I hope this answers your query.
Let me know if I need to assist you further.
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