Patient's Query
Hello doctor,
I am a 37-year-old female. I have increased pain in my pelvis with blood in my urine. I also experience weight loss and fatigue. Do these symptoms indicate the presence of metastatic urothelial carcinoma? I heard about metastatic urothelial carcinoma from my doctor. Is it a carcinoma? How is it caused? How is it diagnosed? What are the other symptoms faced in this metastatic urothelial carcinoma? How is this condition treated? Please help.
Thank you.
Hello,
Welcome to icliniq.com.
I read your query and can understand your concern.
The symptoms you are experiencing may point toward metastatic urothelial carcinoma (a type of cancer that originates in the cells lining the urinary tract), urinary tract infections (infections that affect any part of the urinary system), or kidney stones (hard deposits made of minerals and salts that form inside the kidneys).
Metastatic urothelial carcinoma is a type of carcinoma, meaning it is a cancer that begins in the cells lining the urinary tract, most commonly the bladder. When it becomes metastatic, it means the cancer has spread to other parts of the body, such as the bones, liver, lungs, or lymph nodes. This can happen when the cancer grows and invades nearby tissues or spreads through the bloodstream or lymphatic system.
The causes of metastatic urothelial carcinoma:
Smoking is the biggest risk factor for bladder cancer, as the carcinogens in tobacco are filtered through the kidneys and can damage the bladder lining.
Long-term exposure to certain chemicals in the workplace, such as in the dye, rubber, or textile industries, can increase the risk.
Recurrent bladder infections, kidney stones, or long-term catheter use can increase the risk of bladder cancer.
Radiation therapy or chemotherapy.
Diagnosis of metastatic urothelial carcinoma:
Urine cytology can detect cancer cells shed into the urine.
CT (computed tomography) scans, MRIs (magnetic resonance imaging), or PET (positron emission tomography) scans are used to check for tumors in the bladder and whether cancer has spread to other areas.
Cystoscopy involves inserting a camera into the bladder to look for tumors. A biopsy may be taken during this procedure to confirm the diagnosis.
In a biopsy, tissue samples from the bladder or other areas where the cancer may have spread can help confirm the diagnosis.
Associated symptoms:
Frequent urination or urgency to urinate.
Pain during urination.
Bone pain occurs if the cancer has spread to the bones.
Shortness of breath or coughing if the cancer has spread to the lungs.
Treatment for metastatic urothelial carcinoma depends on the stage and how far the cancer has spread. Common treatment options include:
Chemotherapy: Often the first line of treatment to slow the spread of cancer and reduce symptoms.
Immunotherapy: Drugs that help your immune system recognize and attack cancer cells.
Targeted therapy: In some cases, if specific genetic mutations are found, targeted therapies may be used.
Radiation therapy: This can help relieve symptoms if the cancer has spread to the bones or other areas, causing pain.
Surgery: Sometimes surgery may be necessary to remove the tumor or relieve blockages caused by the cancer.
A physical examination by your oncologist in a hospital is a must.
I hope I have answered your question.
Let me know if I can assist you further.
Thank you.
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Answered byDr. Sugandh Garg
Medically reviewed byiCliniq medical review team
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