Is it advisable to take Udiliv continuously to lower SGPT levels?

Hello,

Welcome to icliniq.com.

I read your query and understood your concern. First of all, it is not very wise to start and stop the medicines like Ursodeoxycholic acid because the medications like it (hepatoprotective agent) are at times the last resort of treatment. Starting and stopping medicines while only measuring SGPT (serum glutamic pyruvic transaminase) levels and not DNA (deoxyribonucleic acid) and other liver tests, can potentially increase the resistance to such drugs. Since you have stopped the treatment at the moment, it is an opportunity to check complete liver studies and HBV (hepatitis B) values, before second time starting the treatment. I suggest you some testing, kindly get them done, or if already done recently, just upload the laboratory test results. I suggest you consult a specialist, talk with them and take the medications with their consent. I hope this has helped you. Kindly follow up if you have more doubts.

Thank you.

Based on your test results, I suggest you initiate the treatment with a tablet of Tenofovir 300 mg once daily. This antiviral therapy will help regulate your HBV infection. There is no treatment available to completely cure HBV infection. While various medications can effectively control viral replication and provide optimal management, they cannot entirely eliminate the virus from the body. Hence, treatment is typically required for the long term, with exceptions for specific situations where treatment can be halted after careful reassessment. This medication might have certain side effects, including the risk of kidney injury. However, such instances are infrequent and can be managed if detected by discontinuing tenofovir and switching to an alternative antiviral therapy. I would also like to inquire if you have any concerns about the cost. There is an alternative medication called Tenofovir Alafenamide, which comes in a 25 mg dose. It is a refined form of Tenofovir with the same effectiveness and a more favorable side effect profile. However, be aware that this drug might not be universally accessible and can be expensive. In any case, beginning treatment is necessary. Furthermore, I would require additional tests to ensure your kidney function is satisfactory. I hope this has helped you. Kindly follow up if you have more doubts.

Thank you.

Hello,

Welcome back to icliniq.com.

I read your query and understood your concern. Firstly, I would like to inform you that, the challenge with hepatitis B infection is that it has a tendency to persist within the body. The virus can rapidly replicate, leading to an increase in the DNA value. The virus progresses through four stages as mentioned below:

1. HbeAg positive and Immunotolerant phase.
2. HbeAg Immunoreactive phase.
3. HbeAg negative immunotolerant phase (carrier stage).
4. HbeAg Immunoactive phase.

You are currently in the HbeAg negative immunoactive phase. Last year, you were in the HbeAg negative Immunotolerant phase. Traditionally, treatment was reserved for immunoactive phases. However, nowadays, antiviral therapies are administered across all four stages due to accumulating evidence and research supporting this approach. It is good that you have decided to initiate Tenofovir Alafenamide 25 mg once daily. You can inquire at your local pharmacy for the available brand in your country of residence. I have also reviewed your reports (attachments removed to protect the patient’s identity), and they appear to be within normal ranges. While your AFP is important, I suggest you undergo the test whenever feasible, as it holds significant importance. Once you have conducted the AFP test, kindly follow up with me. Additionally, another follow-up should occur after three months of taking Tenofovir Alafenamide. This follow-up should include the following tests:

1. Alpha-fetoprotein (AFP)
2. Complete Blood Count (CBC).
3. Serum SGPT: Serum Alanine Aminotransferase (SGPT).
4. Serum SGOT: Serum Aspartate Aminotransferase (SGOT).
5. HBV DNA quantitative PCR: Hepatitis B Virus DNA quantitative Polymerase Chain Reaction.

I suggest you consult a specialist, talk with them and take the medications with their consent. I hope this has helped you. Kindly follow up if you have more doubts.

Thank you.