Why do I have a persistent reactive syphilis test result?

Question

Hi doctor,

I am a 37 year old married female. Five years ago, I got a job offer in abroad. When I had a medical checkup, I was found to be positive for VDRL and TPHA reactive. But, my husband's result was nonreactive.

I took medicine as advised by my doctor. Now, when I went for a checkup, again the result came as reactive. I am much worried. I never went wrong with any person. Why am I getting the result as reactive?

Please help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

Firstly, VDRL (venereal research laboratory test) test usually becomes negative after successful treatment.

However, TPHA - Treponema pallidum hemagglutination assay will remain positive throughout life. Positive TPHA just indicates that you have developed antibodies and immunity against syphilis. It does not indicate infection.

However, if VDRL is still positive, then you need to get retreated with injection Benzathine penicillin 2.4 million units single intramuscular dose after testing from the local doctor.

Testing for titers of VDRL is important. It is possible that titers have fallen significantly and it is positive in very low level. If such is the case, then no treatment is needed.

It is recommended that the patients with positive syphilis should also get other viral tests like HBsAg (hepatitis B surface antigen), Anti-HCV (hepatitis C virus antigen) and HIV (human immunodeficiency virus).

I hope this helps.

Thank you.