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How can I cure syphilis through medication?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I have the first stage of syphilis. I came to know about this last month. For the past three weeks, I have been under treatment and taking Doxycycline 100 mg capsule twice a day. I took this medication for 15 days. Yesterday, I had a blood test done for VDRL (Venereal Disease Research Laboratory), and my value is reactive (1:4).

Also, the ulcer on my penis head has not yet healed. I was asked to apply povidone-iodine 10 % ointment on the ulcer. Should I go for Penicillin treatment? I got tested for HIV-1 and HIV-2 tests (Human Immunodeficiency Virus) and CMIA (Chemiluminescence Microparticle Immunoassay)a month back with a value of 0.15, and ten days before, the value was 0.13.

Currently, I am consulting a dermatologist. Should I switch to a sexologist for syphilis treatment? Also, please suggest what diet I should follow to overcome this disease?

Kindly guide.

Thank you.

Hi,

Welcome to icliniq.com.

I understand your concern.

Penicillin is the most definitive treatment for syphilis, but get the allergy test done before taking the full treatment. Apply Mupirocin ointment twice a day on the Ulcer. Continue your doctor's treatment as he or she is examining you in person, so they are the best judge for the line of management.

I hope this helps.

Thank you.

Patient's Query

Hi doctor,

Thank you for the reply.

One more question, today I had nucleic acid testing for HIV-1 (RNA), the test result was lower than the detectable limit. I am not sure what this means. Does this mean that I do not have HIV, or should I wait for the three-month window period to complete to check once again?

I went for an HIV (human immunodeficiency virus) RNA (ribonucleic acid) test, as someone suggested that it can detect if HIV is present within a nine-to-11-day window period.

Please advise.

Hi,

Welcome back to icliniq.com.

I understand your concern.

What I could understand is that this was a PCR test for HIV RNA. I need to know the time duration since the exposure to be able to comment for sure. Fourth-generation ELISA (Enzyme Linked Immunosorbent Assay) test is to be done at six weeks and repeated at three months to be sure. The PCR (Polymerase Chain Reaction) test comes back positive in three to four weeks.

I hope this helps.

Thank you.

Patient's Query

Hi doctor,

Thank you for the reply.

I was exposed two months back.

Hi,

Welcome back to icliniq.com.

Get a fourth-generation ELISA (Enzyme Linked Immunosorbent Assay) for HIV 1 and HIV-2 done at three months from exposure to be sure.

I hope this helps.

Thank you.

Medically reviewed byiCliniq medical review team

Published At March 4, 2018
Reviewed AtDecember 26, 2025

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