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Does intake of Sulfamethoxazole-Trimethoprim cause renal failure?

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Patient's Query

Hi doctor,

I am a 60-year-old male. I took Sulfamethoxazole-Trimethoprim 400/80 mg three times a day for three consecutive days. I got a serum creatinine level of 2.25 mg/dL, EGFR of 29 ml/minute, and albumin to creatinine ratio of 430 mcg/L in my renal function tests. My urine sample is yellow with slight turbidity. I have a normal urinalysis. I do not have oliguria. Everything is normal without any abnormal symptoms. I am taking Bisoprolol 10 mg for hypertension. I am not diabetic. Does taking a course of Sulfamethoxazole-trimethoprim cause this kind of result that mimics renal failure?
Answered by Dr. Mohammed Abdul Nasir

Education:

MD

Professional Bio:

Dr. Mohammed Abdul Nasir is an expert in Internal Medicine, with extensive experience and a deep understanding of all treatment modalities within the field.

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Hi,

Welcome to icliniq.com.

I have gone through your problem. There are many cases in the literature showing that acute kidney injury occurs with the initiation of Cotrimoxazole therapy. This relation occurs more commonly in elders and so increased creatinine occurs due to acute kidney injury caused due to Cotrimoxazole therapy. This relation can be clearly established when creatinine comes back to normal after stopping the therapy.

Treatment plan

Stop taking Cotrimoxazole.

Regarding follow up

You can repeat creatinine after three to four days of stopping Cotrimoxazole.
Answered by
Medically reviewed by Dr. K. Shobana
Published At December 9, 2020
Reviewed At July 18, 2023

Education:

MD

Professional Bio:

Dr. Mohammed Abdul Nasir is an expert in Internal Medicine, with extensive experience and a deep understanding of all treatment modalities within the field.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Education:

BDS

Professional Bio:

Dr. K. Shobana is a Dental Surgeon specializing in oral health and dental care. She is skilled in preventive dentistry and provides oral hygiene education. She can do restorative treatments such as fillings and crowns. She can handle periodontal problems such as gum diseases and periodontitis. She can do root canal treatment.

This doctor is not available for online consultations on the platform anymore.

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Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Mohammed Abdul Nasir

Pain Medicine

Education:

MD

Professional Bio:

Dr. Mohammed Abdul Nasir is an expert in Internal Medicine, with extensive experience and a deep understanding of all treatment modalities within the field.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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