Is Semaglutide causing numbness and tingling in the hands?

Question

Hello doctor,

I am 49 years old with prediabetes and started compounded Semaglutide four weeks ago. The weight loss has been remarkable; I have already lost 18 pounds. However, I am now experiencing increasing numbness and tingling in my hands and feet. It is getting worse each day.

The pharmacist told me this could be normal, but I work as an electrician and need a full sensation in my fingers. This is starting to affect my ability to do my job.

Is this a known side effect of Semaglutide? Could it be neuropathy? If so, is there a risk it could become permanent? Should I stop the injections immediately, or is this something that might resolve over time? Unfortunately, my doctor is on vacation for another week, and I am unsure what to do in the meantime. Please help.

Thank you.

Answer 1

Hi,

Welcome to icliniq.com.

I read your query and can understand your concern.

There is currently no strong evidence that compounded Semaglutide directly causes permanent peripheral neuropathy (a condition where the nerves outside the brain and spinal cord are damaged, causing pain, numbness, or weakness, usually in the hands and feet). However, some patients using compounded weight loss medications have reported symptoms like numbness and tingling in the hands and feet. These symptoms are typically temporary and may improve after stopping the medication, although recovery can take several weeks or even months.

While Semaglutide does have some known side effects, including rare cases of vision changes, numbness, and tingling, these are not commonly reported in clinical trials of FDA (Food and Drug Administration)-approved versions. That said, compounded versions can vary in quality and formulation, which may contribute to unexpected reactions.

At this point, unless your symptoms are rapidly worsening or disabling, it may not be necessary to stop the medication immediately. Abruptly discontinuing Semaglutide can reverse its beneficial effects, especially for blood sugar control and weight loss. It would be best to wait until your doctor returns and discuss a gradual tapering plan under their supervision, if needed.

In the meantime, monitor your symptoms closely. If they become severe or start affecting your ability to function, seek in-person medical attention.

I hope this helps.

Kindly revert so I can assist you further.

Thank you.