When can blood clot or PE develop?

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Usually, there is always an underlying risk factor for the development of deep vein thrombosis. Advanced age, genetic conditions, smoking, obesity, trauma, surgery, etc., are some of the risk factors. Genetic disease includes protein C deficiency, protein S deficiency, prothrombin gene mutation, etc. So it can be ruled out by full coagulation profile testing. Low molecular weight Heparin and oral anticoagulant drug like Apixaban are the modes of treatment for that. Usually, there is always some risk factor present for PE (pulmonary embolism).