What can cause low platelets and giant platelets?

Question

Hello doctor,

I am a 33-year-old male with having low platelets range of 60000 to 85000 platelets per microliter of blood since the last month. The first time checked for platelet was one month ago. Giant platelets are seen in PBS (150000 around peripheral smear). No atypical cells were seen. TSH, T3, T4, LFT, RFT, USG of the abdomen (normal). ANA, HIV, HbsAg, HCV, dengue, malaria negative. RDW, MPV, albumin, and ALT little high. Please help.

Answer 1

Hi,

Welcome to icliniq.com.

I understand your concern.

According to the history provided, your MPV (mean platelet volume) value is high, your platelet count is low, and giant platelets are present in the smear. Hence, thrombocytopenia (low platelet) can be from increased platelet destruction (giant platelets are counted as RBCs (red blood cells) in the cell counter, so if the peripheral smear count is 1.5 million cells/mcL, then it can be considered normal rather than low platelet). All laboratory reports (attachments are hidden to protect the patient's identity) are normal. Hence, this could be from any viral infection. Your clinical correlation is necessary in such cases. The liver, spleen, and lymph nodes should be palpated, and a physical examination should be done. Drinking more water and papaya juice is also beneficial. Avoid alcohol consumption. Sometimes platelet destruction can be from certain drug-induced causes. To provide any drug history if present. Consult a physician for examination.

Hope your concern is solved.

Take care.