Patient's Query
Hello doctor,
I had my mid-cycle scan yesterday on CD 11 after taking 5 mg of Femara from days two to six. My reproductive endocrinologist informed me that I should be ovulating soon. However, despite testing with multiple ovulation predictor kits throughout the day, all results have been negative.
Yesterday, I had two follicles measuring 18 mm and 20 mm. Any insights on why my luteinizing hormone surge has not occurred yet? I am concerned about my follicles growing too large.
Please help.
Thank you.
Hello,
Welcome to icliniq.com.
No one likes to hear this, especially women, but your weight may be a contributing factor. You might have PCOS (polycystic ovary syndrome)/PMOS (polyendocrine metabolic ovarian syndrome). PCOS/PMOS is a congenital condition, meaning it is genetically programmed and inherited from your parents.
When you gain weight, the excess cholesterol in your body can convert into estrogen hormones. This conversion can disrupt the balance between follicle-stimulating hormone (FSH) from the brain and the ovarian hormones.
FSH stimulates follicle growth in the ovary, but once the follicle reaches a sufficient size for ovulation, the estrogen hormone from the ovary suppresses FSH. However, when excess estrogen hormone comes from fat, it can confuse the brain, resulting in the early cessation of follicle growth at a smaller size, which prevents ovulation.
These follicles become resistant to luteinizing hormone (LH) and continue to grow, eventually forming cysts. During your next scan, you may observe these cystic follicles, commonly known as polycystic ovaries.
PCOS (polycystic ovarian syndrome)/PMOS (polyendocrine metabolic ovarian syndrome is a condition that is often associated with the following:
However, there are solutions available to address concerns related to PCOS/PMOS. I suggest you do the following:
Since your goal is pregnancy, you want a healthy egg to be released from the ovary at the right time, with the endometrium (uterine lining) having the appropriate thickness. This will optimize the chances of the egg meeting the best sperm for successful embryo formation.
Ideally, you would want the egg to be released around the 12th to 15th day of your menstrual cycle, rather than randomly when the cyst happens to rupture. Taking a few months to gradually lose weight can significantly improve your chances of getting pregnant, eliminating the need for frequent follicular scans and follow-ups.
I hope this information helps you.
Do write back if any more queries.
Thank you.
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Answered byDr. Balakrishnan. R
Medically reviewed byiCliniq medical review team
Same symptoms don't mean you have the same problem. Consult a doctor now!
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