What is NIFTP in a patient with follicular variant of papillary cancer?

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I understand your concern and will help you regarding it. I have seen the attached provisional report (attachment removed to protect the patient's identity). The diagnosis of a follicular variant of papillary cancer requires a capsular invasion by tumor cells on histopathological resection specimens. If the capsular invasion is not present even after extensive examination, it is not a follicular carcinoma. As described in the attached report, the lesions have shown evidence of indolent biological behavior (lack of metastasis or recurrence). Due to that, the suggested name is "Noninvasive follicular thyroid neoplasm with papillary-like nuclear features"- NIFTP. Diagnosis of NIFTP requires surgical excision specimen with a complete evaluation of the tumor to normal interface to exclude capsular invasion. The long-term survival and prognosis are excellent. The above report shows no evidence of capsular invasion, even after extensive sectioning. The nuclear features are papillary carcinoma, and the cellular arrangement is that of a follicular lesion. Hence the diagnosis of NIFTP seems appropriate. I hope this helps. Take care and all the best.

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Yes, NIFTP (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) has an indolent disease course with excellent long-term survival following surgical resection. It is believed that tumor excision is sufficient, and no extended surgery, radioiodine ablation (RAI), and TSH suppression therapy are required. I wish health and peace to you. Take care.