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Will Depakote XR drug cause Parkinson's disease?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am suffering from OCD and doctor prescribed Depakote XR 500 mg and Paroxetine CR 25 mg, which I am taking for last eight years. I read that these medicines can cause drug-induced Parkinson's. Please advise how to stop taking these medicines without withdrawal symptoms.

Answered by Dr. Vishal Anilkumar Gandhi

Education:

MBBS

Professional Bio:

Dr. Vishal Anilkumar Gandhi is a Psychiatrist with expertise in diagnosing and treating mental health disorders such as depression, anxiety, bipolar disorder, and schizophrenia. He is skilled in psychotherapy, pharmacological management, crisis intervention, and counseling. Dr. Gandhi focuses on holistic patient care, mental wellness, and improving the quality of life through tailored treatment approaches.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

I do not think that those medications can induce Parkinson's. Antipsychotic drugs are more common to induce extrapyramidal symptoms like Parkinson's. Still, if you want to stop it, then you need to taper off over months gradually. It may lead to worsening your OCD.

Patient's Query

Thank you doctor,

I have one more major problem. I am taking Nitrazepam 10 mg for last one year, and now I want to leave it. Please guide me in detail as to how to taper this medicine because Depakote XR 500 which I take is known to increase the effect of Nitrazepam several times. Can I taper off at home and how?

Answered by Dr. Vishal Anilkumar Gandhi

Education:

MBBS

Professional Bio:

Dr. Vishal Anilkumar Gandhi is a Psychiatrist with expertise in diagnosing and treating mental health disorders such as depression, anxiety, bipolar disorder, and schizophrenia. He is skilled in psychotherapy, pharmacological management, crisis intervention, and counseling. Dr. Gandhi focuses on holistic patient care, mental wellness, and improving the quality of life through tailored treatment approaches.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome back to icliniq.com.

I think that you are taking Nitrazepam at night for sleep disturbance. You can taper off gradually. It makes a problem initially. You need to make it half (5 mg) for two weeks. Once you stable with it, then take 5 mg Nitrazepam for alternate days for another two weeks. Than take for twice a week for two weeks and continue as needed. I hope you understood.

Medically reviewed by Dr. Nithila. A
Published At June 12, 2019
Reviewed At May 2, 2024

Education:

MBBS

Professional Bio:

Dr. Vishal Anilkumar Gandhi is a Psychiatrist with expertise in diagnosing and treating mental health disorders such as depression, anxiety, bipolar disorder, and schizophrenia. He is skilled in psychotherapy, pharmacological management, crisis intervention, and counseling. Dr. Gandhi focuses on holistic patient care, mental wellness, and improving the quality of life through tailored treatment approaches.

This doctor is not available for online consultations on the platform anymore.

Education:

BDS

Professional Bio:

Dr. Nithila A is a Dental Surgeon specializing in providing comprehensive oral healthcare. She focuses on preventive care, routine dental treatments, and patient education to maintain optimal oral health. Known for her compassionate and patient-centered approach, she ensures comfortable and effective dental care tailored to the individual needs of each patient.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Vishal Anilkumar Gandhi is a Psychiatrist with expertise in diagnosing and treating mental health disorders such as depression, anxiety, bipolar disorder, and schizophrenia. He is skilled in psychotherapy, pharmacological management, crisis intervention, and counseling. Dr. Gandhi focuses on holistic patient care, mental wellness, and improving the quality of life through tailored treatment approaches.

This doctor is not available for online consultations on the platform anymore.

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