Patient's Query
Hi doctor,
An elderly family member was diagnosed with overlap myeloproliferative or myelodysplastic disorder two years back. He is being treated by a hematologist who arranges regular blood tests and he is said to be "hematological stable".
His appetite has been in decline for a while. He does not experience night sweats at all and I am told that he does not have an enlarged spleen. What sort of physical changes might alert us if he develops an acute transformation? He is currently being treated with Hydroxyurea.
Please help.
Thank you.
Hi,
Welcome to icliniq.com.
I hope you are doing well in the pandemic. The acute transformation has clinical signs and symptoms of acute leukemia, such as recurring fever not responding to antibiotics, pallor, dyspnea, shortness of breath due to low hemoglobin, bruising and bleeding due to low platelets, loss of appetite and weight, lethargy, malaise, and generalized bone pains. Do the blood tests regularly. Keep an eye on the cytogenetic abnormalities as these appear months before physical changes.
I hope this helps.
All the best.
Patient's Query
Hi doctor,
Thank you, doctor.
This is extremely useful information. There is one more point that I would like to check with you. Obviously, not all cases are the same and you are not in a position to personally treat my family member. But could you please tell me what is the average or mean period of time that people with overlap myeloproliferative or myelodysplastic disorder live from the time of diagnosis?
Please answer.
Thank you.
Hi,
Welcome back to icliniq.com.
It depends upon the baseline conditions. For example, the patient with only unilineage refractory cytopenia, with blast cells less than 1 %, might take decades to evolve into a blast transformation (leading to death) if left untreated. In the case of patients having multiple cytopenias with 5 to 19 %, blasts would take less than a year to develop a life-threatening disease. Please send me a baseline workup and a fresh CBC (complete blood count) report for a more elaborative comment.
I hope this helps.
Thank you.
Was this conversation helpful?
Same symptoms don't mean you have the same problem. Consult a doctor now!
Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.
