Is Ocrelizumab safe for long-term MS treatment?

Question

Hello doctor,

I am a 50-year-old man with multiple sclerosis, and I have been on Ocrevus (Ocrelizumab) for the past year. While it seems to have reduced the frequency of my flare-ups, I have been experiencing a lot of fatigue and occasional dizziness. Are these side effects of the medication, or could they be related to my MS itself? Before Ocrevus, I was on Tecfidera (Dimethyl fumarate), but I had to switch because of stomach issues. How can I tell if Ocrevus is the right long-term treatment for me? I am also taking Baclofen for muscle spasms and Amitriptyline for nerve pain, but sometimes the pain and stiffness feel unmanageable. Should I discuss adjusting my dosages with my doctor? Lastly, are there any new medications or alternative therapies I should be aware of that might help manage my condition better?

Please help.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

I am sorry for the health problems you are going through.

I am happy to hear your current treatment with Tysabri (Ocrelizumab) is reducing the flare-ups. However, as with any other medicine, it comes with side effects such as fatigue. As it is associated with dizziness, I highly recommend measuring your blood pressure and blood sugar levels when you have dizziness flare-ups, to understand the real culprit.

In case they are within normal limits, and the pain and fatigue are unbearable and not well managed with current medications (Amitriptyline and Baclofen), I highly recommend discussing changes in therapy with your caring doctor.

I also recommend some physical therapeutic exercises, like stretching and strengthening exercises, which can reduce stiffness and improve mobility.

I hope this has helped you.

Please feel free to reach me again, in case of further queries.

Thank you.