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Does COVID-19 have an impact on my husband's MGUS FLC test?

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Patient's Query

Hi doctor,

My husband was diagnosed with FLC MGUS (monoclonal gammopathy of undetermined significance) 13 years ago. All laboratory test results were completely normal except for his FLC (free light chains) ratio. He is monitored annually. This FLC ratio rose from 12 to 21.

He had COVID-19. His haematologist suggested that we repeat because of COVID. Unfortunately, he got COVID again. We repeated the test, and they went up. Everything else, other than the FLC ratio, is completely normal.

Is COVID affecting this FLC test? I have all the test results and can submit them for your review.

Please help.

Thank you.
Answered by Dr. Rajesh Gulati

Education:

MBBS

Professional Bio:

Dr. Rajesh Gulati is a Family Physician with 21 years of clinical experience. He did his MBBS from Goa Medical College in 2002. Later, he pursued his Post Graduate Diploma in Geriatric Medicine from Indira Gandhi Open University in 2008. He expertise in Geriatrics and Medical Oncology. He can communicate in Hindi and Punjabi. He also works as SME in Clinical Abstraction Oncology.

This doctor is not available for online consultations on the platform anymore.

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Hi,

Welcome to icliniq.com.

I read your query and understand your concern.

It is free kappa that is high. I hope you have checked serum protein electrophoresis (SPE) for the M spike. If the M spike is negative, no treatment is needed at present. If the M spike is positive, you need treatment.

If the M spike is negative, I suggest you repeat CBC (complete blood count), KFT (kidney function tests), serum free light chain ratio, and SPE for the M spike after three months.

I hope this helps.

Thank you.

Patient's Query

Hi doctor,

Thank you for your reply.

Yes, his M spike is negative. Could COVID have increased this ratio? What treatment would he need?

Please help.

Thank you.

Answered by Dr. Rajesh Gulati

Education:

MBBS

Professional Bio:

Dr. Rajesh Gulati is a Family Physician with 21 years of clinical experience. He did his MBBS from Goa Medical College in 2002. Later, he pursued his Post Graduate Diploma in Geriatric Medicine from Indira Gandhi Open University in 2008. He expertise in Geriatrics and Medical Oncology. He can communicate in Hindi and Punjabi. He also works as SME in Clinical Abstraction Oncology.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Hi,

Welcome back to icliniq.com.

COVID can increase the ratio, but there is no proven data. Since the M spike is negative, you should not worry. No treatment is needed at present. But repeat the tests after three months.

I hope this helps.

Thank you.

Medically reviewed by iCliniq medical review team
Published At October 11, 2023
Reviewed At May 25, 2026

Education:

MBBS

Professional Bio:

Dr. Rajesh Gulati is a Family Physician with 21 years of clinical experience. He did his MBBS from Goa Medical College in 2002. Later, he pursued his Post Graduate Diploma in Geriatric Medicine from Indira Gandhi Open University in 2008. He expertise in Geriatrics and Medical Oncology. He can communicate in Hindi and Punjabi. He also works as SME in Clinical Abstraction Oncology.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Rajesh Gulati
Dr. Rajesh Gulati

Family Physician

Consult this doctor

Education:

MBBS

Professional Bio:

Dr. Rajesh Gulati is a Family Physician with 21 years of clinical experience. He did his MBBS from Goa Medical College in 2002. Later, he pursued his Post Graduate Diploma in Geriatric Medicine from Indira Gandhi Open University in 2008. He expertise in Geriatrics and Medical Oncology. He can communicate in Hindi and Punjabi. He also works as SME in Clinical Abstraction Oncology.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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