How does the malaria vaccine affect frequent bouts of malaria episodes?

Question

Hello doctor,

I am a 38-year-old male. I have experienced malaria three times in recent years, despite assuming that one episode would grant immunity. I came across information online about a potential malaria vaccine, and considering my job, which involves frequent travel to underdeveloped regions in Southeast Asia and Africa throughout the year, I am contemplating the impact on my future plans.

Could you provide clarity on the development of a malaria vaccine, its potential side effects, and any insights into its availability? I am particularly interested in understanding if this could influence my decision regarding retirement. Additionally, I am curious about the priority groups for vaccine distribution.

Thank you for your guidance.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and understand your concern.

There are two malaria vaccines endorsed for broader use by the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC):

RTS,S/AS01 (RTS,S): Developed by GlaxoSmithKline, this vaccine is the first to be recommended for children aged 6 months to 17 months living in sub-Saharan Africa and regions with moderate to high malaria transmission. Administered in four doses, starting at six months of age with subsequent doses given monthly, the vaccine has an efficacy of approximately 30-40 percent. While it is only partially effective at preventing malaria, it is notably effective in preventing severe malaria and related deaths.
R21/Matrix-M: A newer vaccine currently under evaluation, it exhibits higher efficacy, around 70 percent, compared to RTS,S. However, it is still in the developmental stage and not yet available for routine use.

The RTS,S vaccine is generally safe and well-tolerated, with common side effects including pain, redness, and swelling at the injection site, as well as mild symptoms like fever, headache, and fatigue. These side effects typically resolve within a few days.

RTS,S vaccine is recommended for children in sub-Saharan Africa and other malaria-prone regions, as well as for travelers unable to take antimalarial medication. This can be used in conjunction with antimalarial drugs for added protection. The CDC advises all travelers to malaria-endemic areas to take antimalarial medication as a preventive measure.

I hope this information provides clarity. If you have any further questions, feel free to ask.

Thank you.