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Why is there a painful lump in my armpit post-flu shot?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I got the influenza vaccination about a week ago and have a swollen and painful lump in my armpit.

Hi,

Welcome to icliniq.com.

I understand your concern. You are having lymph node swelling axillary post influenza vaccination. Influenza vaccine is a very safe vaccine. Although some may have local pain, swelling, and fever. Some may have local lymphadenopathy.

Lymphadenopathy is a swelling of lymph node (normal gland present in our body, which function as clearing harmful substances and providing immunity). Local and systemic reactions mostly began between day 1 and day 2.

When a lymph node rapidly increases in size, its capsule stretches and causes pain. Pain is usually the result of an inflammatory process. It is a reactive response of the lymph node to the vaccination. So no need to worry.

It can be managed by simple Paracetamol or anti-inflammatory medication such as Serratiopeptidase. It should resolve within a week. If it is associated with fever or any other site enlargement of lymph node you can visit your physician.

I hope this helps.

The Probable causes

Reactive lymphadenitis.

Investigations to be done

CBC (complete blood count), ESR (erythrocyte sedimentation rate), USG (ultrasound) axillary lymph node.

Differential diagnosis

Lymphadenopathy.

Treatment plan

anti-inflammatory Paracetamol 500 mg twice or thrice daily or Aceclofenac, Paracetamol, and Serratiopeptidase combination tablet twice daily for three days.

Regarding follow up

Follow up after three days.

Medically reviewed byDr. Vinodhini J.

Published At May 6, 2020
Reviewed AtMay 19, 2026

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