How to treat the problem in the liver accompanied by spleen enlargement in a young patient?

Hello doctor,

My nephew who is about to become a teenager has been suffering for more than seven years. Two years after his birth he used to have a poor appetite and constipation. Back overseas he underwent many laboratory tests like myelogram, biopsy, and ultrasound. He has a medical history of fever, severe anemia, a big and hurting tummy, chest pain, and vomiting blood. He recently moved to another country overseas where he has been admitted three times for blood transfusion. He was admitted for the first time before seven months, the second time before six months, and recently for the third time during the last month when he was transfused with eight packs of blood. He also vomited blood as he did almost one year back during his latest hospital admission due to four varicose veins in the esophagus. A Fibroscan and liver biopsy were done during the last two months which revealed that the spleen is enlarged. He has consulted an oncologist, a hematologist, and a liver surgeon. Lately, the surgeon has told that they have detected a problem in the liver but they are not certain whether they will do a spleen ablation, as they have not found the cause of the disease yet. The liver cirrhosis and sickle cell hypothesis were set aside as the doctors did not find any conclusive elements to validate those. The laboratory tests he has undergone are myelogram, histopathology, electrophoresis, Fibroscan, CT scan abdomen, hepatitis, chest X-ray, endoscopy, blood chemistry, liver biopsy, liver ultrasound with Doppler in the last two months, chest radiology, and bone marrow. Earlier he was taking Cotipred and his current medications are Folic acid and Propranolol 10 mg. I have attached the reports of all his laboratory tests and the latest abstracts released by the hospital where he is currently undergoing treatment.

Kindly help.