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Does raised kappa level indicate multiple myeloma?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I have been diagnosed with CKD, and my GFR is 52. My recent blood test results show the following information. Kappa QNT free LT chains 41.60 mg/dL, lambda QNT free LT chains 0.96 mg/dL, KAP/LAM free LT chain ratio 43.33 and hemoglobin 15.8 g/dL. I was also detected with vitamin D deficiency, and the parathyroid test shows 118 pg/mL. Does this mean I have multiple myeloma? What other tests need to be performed to confirm it?
Answered by Dr. Anshul Varshney

Education:

MBBS

Professional Bio:

Dr. Anshul Varshney is a highly skilled Critical Care Physician specializing in nephrology, pulmonology, and rheumatology. He is committed to providing advanced, life-saving care to critically ill patients while addressing complex medical conditions affecting the kidneys, lungs, and immune system. His holistic and multidisciplinary approach ensures comprehensive treatment tailored to individual patient needs.

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Hi,

Welcome to icliniq.com.

We are here to help you.

  • A diagnosis of any disease is based on the symptoms and laboratory work. I need the following details to help you better.
  • Why were these tests performed? Do you have bone pain or any night sweats or any weight loss?

Revert with the details to a nephrologist online.

Patient's Query

Hi doctor,

The reason for the test is decreased kidney function below 60 GFR. There is no night sweats, no weight loss and no bone pain. I have attached a copy of my blood work.

Answered by Dr. Anshul Varshney

Education:

MBBS

Professional Bio:

Dr. Anshul Varshney is a highly skilled Critical Care Physician specializing in nephrology, pulmonology, and rheumatology. He is committed to providing advanced, life-saving care to critically ill patients while addressing complex medical conditions affecting the kidneys, lungs, and immune system. His holistic and multidisciplinary approach ensures comprehensive treatment tailored to individual patient needs.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Hi,

Welcome back to icliniq.com.

I have studied your attached reports (attachment removed to protect patient identity).

  • Yes, definitely kappa levels are raised, but your calcium levels are within normal limits. In such case, immunoelectrophoresis is suggestive. But, it is not conclusive of multiple myeloma.
  • I would recommend in such case a bone marrow examination and biopsy to get a conclusive result and urine for Bence Jones protein.

For further information consult a nephrologist online.

Medically reviewed by iCliniq medical review team
Published At January 30, 2017
Reviewed At June 23, 2026

Education:

MBBS

Professional Bio:

Dr. Anshul Varshney is a highly skilled Critical Care Physician specializing in nephrology, pulmonology, and rheumatology. He is committed to providing advanced, life-saving care to critically ill patients while addressing complex medical conditions affecting the kidneys, lungs, and immune system. His holistic and multidisciplinary approach ensures comprehensive treatment tailored to individual patient needs.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

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Dr. Anshul Varshney

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Education:

MBBS

Professional Bio:

Dr. Anshul Varshney is a highly skilled Critical Care Physician specializing in nephrology, pulmonology, and rheumatology. He is committed to providing advanced, life-saving care to critically ill patients while addressing complex medical conditions affecting the kidneys, lungs, and immune system. His holistic and multidisciplinary approach ensures comprehensive treatment tailored to individual patient needs.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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