How can the blood report of a person with jaundice help rule out leukemia and other blood disorders?

Question

Hello doctor,

I am suffering from jaundice (yellow eye). Blood tests indicate high indirect bilirubin, high reticulated cell count, high hemoglobin F, low haptoglobin, positive direct coombs test, tested negative for lupus, RBC (red blood cells) was low last month, but now normal. WBC (white blood cells)are normal, but granulocytes are elevated. No G6DP deficiency. Urine tests are normal. These tests appear to reflect idiopathic warm body autoimmune hemolysis. But how do I rule out some type of leukemia or other blood diseases? MRI (magnetic resonance imaging) indicates no liver, kidney, or pancreas anomalies. The spleen is slightly enlarged but does present pain or fullness. Gallstones are small and doctors do not think they are causing the problem. No other physical symptoms.

Kindly help.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

The spleen enlargement can be due to hemolysis because of autoimmune hemolytic anemia. In hemolytic anemia, gall stone also occurs as a complication. To rule out leukemia a full CBC (complete blood count) and peripheral smear examinations are beneficial. If there is doubt in the CBC report then higher investigations like flow cytometry can be planned.

I hope I have answered your question. Let me know if I can assist you further.

Best regards,

Thank you.