What is the effectiveness of hormone therapy in breast cancer?

Question

Hello doctor,

My mother, who is 65 years old, has been diagnosed with ER/PR-positive breast cancer and will soon begin hormone therapy. The physician indicated that her estrogen levels are contributing to the cancer's progression, but I have concerns regarding the potential side effects of medications such as Tamoxifen. Additionally, she suffers from osteoporosis, and I have heard that these treatments may exacerbate her condition. Are there safer alternatives available for her? Furthermore, how effective is hormone therapy in either slowing the progression or potentially curing this type of cancer? We are also interested in knowing if there are any tests available to monitor the therapy's effectiveness. Lastly, does diet or weight loss play a role in managing hormone-receptor-positive cancers?

Kindly help.

Answer 1

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Tamoxifen is a hormone therapy utilized for the treatment of hormone receptor-positive breast cancer. It significantly decreases the likelihood of cancer recurrence and the development of invasive cancer. Additionally, some individuals take Tamoxifen to reduce their risk of developing breast cancer. This daily oral medication inhibits cancer cells from utilizing estrogen and progesterone for growth and proliferation.

The potential side effects of tamoxifen include:

Symptoms similar to menopause, such as hot flashes, night sweats, and vaginal dryness, as well as dysuria and dyspareunia.
Weight gain, which is more common, or fluid retention (edema).
Irregularities in menstrual bleeding or complete cessation of periods.
Swelling in the legs.
Nausea.
Vaginal discharge.
Skin rashes.
Fatigue.
Headaches.
Endometrial hyperplasia may lead to endometrial cancer.

If a patient experiences side effects from tamoxifen, the treatment may be adjusted to include alendronate, with one tablet taken for two months, along with Vitamin D3 supplements at a dosage of 2000 IU.

It is also advisable to consult your breast surgeon about alternative treatment options. They will provide guidance on the best course of action, so there is no need for concern.

I hope this information helps you.

Feel free to ask further queries.

Thank you.