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Is taking basic PEP 12 hours after exposure appropriate?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I was having sexual intercourse with a sex worker when the condom broke. I was distraught, so I ran to a hospital, and they started my first dose of PEP after 12 hours of exposure. The regimen given to me for 28 days is Lamuvidine plus Tenofovir and Lopinavir, and Ritonavir.

Is this regimen right? I talked to another doctor, and he told me this is basic PEP and not of much help. He also prescribed PEP. What to do?

Please help.

Hello,

Welcome to icliniq.com.

I went through your query.

As per my experience, the regimen you are taking is fine. The only drawback is that it may be causing some more side effects like nausea, vomiting, headache, weakness, etc, and hence it is more difficult to take the one your practitioner has advised. You can continue with the PEP (post-exposure prophylaxis) you are already taking and need not stop and start another one, as discontinuing it may do more harm than good.

Hope it helps.

Thank you.

Patient's Query

Hello doctor,

Thank you for your reply.

Does PEP help or am I going to suffer due to my wrong step?

Please help.

Hello,

Welcome back to icliniq.com.

PEP is very helpful and very effective for the prevention of HIV. Do not miss a single dose and take it regularly (even if you experience some mild side effects) and timely daily for it to be most effective.

Thank you.

Medically reviewed byiCliniq medical review team

Published At August 14, 2018
Reviewed AtDecember 19, 2025

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