Patient's Query
Hi doctor,
After 21 months since my HIV (human immunodeficiency virus) diagnosis and have been undetectable for 15 of those months, two months back, I was switched from the effective Truvada or Tivicay regimen to Triumeq. The sole explanation was that STR (single tablet regimen) was more convenient.
I am yet to do labs with Triumeq, but I have three concerns at this point:
Hi,
Welcome to icliniq.com.
It is not at all advised to substitute a regimen with another drug of your own choice based on convenience. The reason is group resistance. The substitute you made is used in the vice versa condition, which is used in case of failure to switch to the second-line medication.
Dolutegravir interacts with antacids, which contain calcium and magnesium salts, and these interfere with absorption, but there is no harm in occasional use, as the drug remains above therapeutic levels for more than five to seven days. Anal activity has a significantly high risk, as there will be no active defense cells and there is increased chances of mucosal tears which increases the chances of HIV transmission. So, he is at risk of transmission.
I hope this helps you.
Thank you.
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Answered byDr. Kiran Anaparthi
Medically reviewed byiCliniq medical review team
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