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What could cause severe hip pain after taking Enzalutamide?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

Severe hip pain developed six months after starting Enzalutamide. A recent scan shows fracture risk. Oncologists recommend taking bone-strengthening medication. What are the risks and benefits of these treatments?

Please suggest.

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Bone-strengthening medications such as Bisphosphonates (Zoledronic acid) or Denosumab, are commonly used to prevent fractures and manage bone density loss in patients on Enzalutamide, which can increase fracture risk. Benefits include reducing bone pain, enhancing bone strength, and preventing fractures. However, risks include potential side effects such as jaw bone problems (osteonecrosis), infections, and low blood calcium levels. Additionally, long-term use may increase the risk of atypical fractures. It is important to discuss the specific medication options with your oncologist to weigh the benefits of fracture prevention against these risks, considering your individual health needs.

I hope this helps.

Thank you and take care.

Medically reviewed byDr. K. Shobana

Published At February 14, 2025
Reviewed AtFebruary 14, 2025

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