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Is Methotrexate effective in treating alopecia areata?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hi doctor,

I am a 31-year-old female. Currently, I have alopecia areata. It got flared up due to my current stress situation. I am looking for a medication to cure it. I heard about Dexamethasone and Methotrexate for treating it. My dermatologist advised me to take Methotrexate. I am concerned about its side effects of hair loss and I do not want to lose more hair.

I am dealing with sporadic hair loss for about three years. I am having hair loss with small patches. But it got developed severely in these five months. I realize that my hair may continue to fall out after stopping medications if I am planning to use it. But I am desperate.

I agree with the side effects of Methotrexate. But I am terrified of having additional hair loss. I am taking a Kenalogue scalp injection every five weeks to treat the condition. Hair grows with injections but it keeps falling out more.

Please help.

Thank you.

Answered by Dr. Deepti Shukla

Education:

MD

Professional Bio:

Dr. Deepti Shukla is a skilled Dermatologist and Venereologist committed to helping patients achieve healthy skin and hair. She provides personalized care for a range of dermatological and cosmetic concerns, including hair disorders, acne, and skin infections. Her approach combines modern treatments with patient-centered guidance to ensure effective and lasting results.

This doctor is not available for online consultations on the platform anymore.

Hi,

Welcome to icliniq.com.

Alopecia areata is a chronic recurrent condition that occurs due to a genetic component. Due to its genetic component, it has a tendency to recur again and again. Both Dexamethasone and Methotrexate are good options.

Taking Methotrexate is better as it causes fewer side effects when compared to Dexamethasone. Depending on the severity and extension of alopecia, treatment can be taken accordingly.

If you have a small patch, then taking a topical steroid or injection is good. If it is extensive, then oral treatment with Methotrexate or Dexamethasone can be taken. Dexamethasone can be used for a short course and Methotrexate can be used for the long term. Taking Methotrexate in a low dose is safe and it will not cause severe hair loss.

I hope it helps.

Thank you.

Medically reviewed by Dr. Sneha Kannan
Published At August 29, 2020
Reviewed At March 3, 2026

Education:

MD

Professional Bio:

Dr. Deepti Shukla is a skilled Dermatologist and Venereologist committed to helping patients achieve healthy skin and hair. She provides personalized care for a range of dermatological and cosmetic concerns, including hair disorders, acne, and skin infections. Her approach combines modern treatments with patient-centered guidance to ensure effective and lasting results.

This doctor is not available for online consultations on the platform anymore.

Education:

BDS

Professional Bio:

Dr. Sneha Kannan is a skilled Dental Surgeon with expertise in providing general dental care, including scaling, fillings, and preventive treatments. She does oral surgery procedures such as extractions and minor surgical interventions. She does procedures in restorative dentistry, including crowns, bridges, and dentures. She is an expert in doing endodontic treatments such as root canal therapy. She is well-versed in doing procedures in cosmetic dentistry, including teeth whitening and smile correction. She can provide pediatric dental care for children’s oral health and preventive treatments. She promotes oral hygiene awareness and preventive dental practices.  

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MD

Professional Bio:

Dr. Deepti Shukla is a skilled Dermatologist and Venereologist committed to helping patients achieve healthy skin and hair. She provides personalized care for a range of dermatological and cosmetic concerns, including hair disorders, acne, and skin infections. Her approach combines modern treatments with patient-centered guidance to ensure effective and lasting results.

This doctor is not available for online consultations on the platform anymore.

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