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Do Aripiprazole tablets cause drug-induced gigantomastia?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I would like to know about drug-induced gigantomastia in women. I am currently taking Aripiprazole, which has caused weight gain and hormonal changes. Specifically, the hormone that binds testosterone is low. Additionally, I have rheumatoid arthritis, an autoimmune condition that may be relevant. My previous medical history includes starting Aripiprazole for schizoaffective disorder when I was 32 years old and weighed 147 pounds. After four to five years of taking the drug, I now weigh 196 pounds and have an increased breast size, which continues to grow. Based on these symptoms, I suspect I have drug-induced gigantomastia. I underwent a prolactin test, and the results came back normal and within the expected range.

Kindly help.

Hello,

Thanks for trusting us with your health care.

I have gone through your history and understand your concerns. You are right; there is a small risk of gynecomastia with antipsychotic drugs as they have prolactin-sparing properties, which can lead to hyperprolactinemia (higher level of prolactin hormone) and gynecomastia (enlargement of breast tissue). It is important to note that other hormonal imbalances can also cause gynecomastia.

I hope this has helped you. Thank you.

Patient's Query

Hello doctor,

Thank you for the reply.

My prolactin levels are normal on this drug, but the hormone that binds to testosterone is abnormally low. Are you saying that this could also affect the situation?

Hello,

Welcome back to icliniq.com

If your testosterone-binding hormone is low, it may also affect the condition and cause gynecomastia. Kindly attach your reports below. Generally, these drugs can cause hyperprolactinemia.

I hope this has helped you. Thank you.

Medically reviewed byiCliniq medical review team

Published At July 14, 2023
Reviewed AtAugust 29, 2023

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Richa Agarwal
Dr. Richa Agarwal

Obstetrics and Gynecology

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