Is factor V Leiden mutation related to any health issues?

Question

Hello doctor,

These are my daughter's bloodwork results that were done nine months ago. I was never told about any of these results until I recently asked for copies of her medical record. This year, she had irregular and heavy menstrual bleeding and developed a large hemorrhagic ovarian cyst with torsion, which had to be removed or corrected with surgery. Now, she is on Tylenol, multivitamins, omega-3 supplements, and Colace (Docusate sodium) for constipation after surgery. Here are her details

Prothrombin time: 13 seconds.
Activated partial thromboplastin time: 32.6 seconds.
Functional protein S: 61% (L).
Free protein S: 92%.
Total protein S: 106%.
Functional antithrombin III: 140% (H).
Factor V Leiden mutation: Single R506Q mutation identified (heterozygote) (H).
Coagulation Factor VIII Activity: 116%.
Von Willebrand Factor: 133%.

I want to ask you

Do these results show her to be at risk for any other issues or health problems?
Should I seek a second opinion?

Kindly suggest.

Thank you.

Answer 1

Hello,

Welcome to icliniq.com.

I have read your query and can understand your concern.

Protein S deficiency causes an increased risk of developing blood-clotting disorders, mainly thrombosis. It can be hereditary or acquired. Acquired protein S deficiency is seen in liver disease or vitamin K deficiency.

Your daughter is heterozygous for the factor V Leiden mutation, which further increases the risk of thrombosis and developing clots. It is advisable that you consult with a hematologist to determine if she might require any monitoring or prophylaxis.

I hope I have answered your query.

Revert in case you have any doubts.

Thank you.