How do antidepressants alter blood glucose levels?

Hello doctor,

Can SNRI antidepressants cause elevated blood sugar and potentially new-onset type 2 diabetes in patients with no family history of type 2 diabetes and no prior issues with blood glucose?

The patient is a 48-year-old with no known health issues aside from chronic pain after cervical trauma, for which Duloxetine 30 mg (milligrams) and Tramadol 50 mg were prescribed several years earlier. The patient follows a healthy diet (low carbohydrates), intermittent fasting, and moderate exercise.

Kindly help.

Hello doctor,

Thank you for the reply.

According to a published article and a package insert for Duloxetine, Duloxetine can raise blood glucose levels and, in some cases, has caused new-onset type 2 diabetes (T2D).

I am concerned because I have pre-diabetic levels of blood glucose. I never had any problem with blood sugar before; my weight is only slightly over normal. I eat keto (less than 30 g (grams) of net carbs per day). No family history of T2D, and exercise regularly. Most people blame the patient themselves for getting type 2 diabetes (saying it is a disease of fat lazy people who eat only junk), and I am so upset at the moment, but I feel in my gut that it is not my fault. I am super restrictive in my diet. I can think of putting on Duloxetine.

Kindly help.