Is it safe to take Bupropion and Nexipride together?

Question

Hi doctor,

I was diagnosed with the somatic symptom disorder. While in anxious situations, it feels like paralysis or nervous breakdown might happen. Also, my hands become cold and my forehead becomes hot. Since the past 1 year, I am on Etizola Beta (Etizolam 0.5 and Propranolol 20) on a total of five tablets a day in the pattern of 2-2-1. Now, this combination does not seem to be that effective and my doctor who has given me the following medications. Clonazepam 0.5 and Nexipride 50 mg in the night, Clonazepam 0.5, Ciplar LA 40 mg, and Bupropion XL 150 mg in the morning and a 0.5 mg Clonazepam in the afternoon. Is it safe to take this combination? The reason why I am asking is that Levosulpiride decreases the effect of D2 dopamine whereas Bupropion increases it by inhibiting the reuptake of dopamine. Is it dangerous to take this combination? Initially, my doctor wanted to recommend me Mirtazapine, but when he found out that my cholesterol levels are high, he switched to Bupropion XL 150 mg. Is it safe to take Bupropion and Levosulpiride together?

Answer 1

Hello,

Welcome to icliniq.com.

There is no interaction between Bupropion and Nexipride (Levosulpiride); hence, no safety issue arises with this combination. Amisulpride is commonly added as an adjunct medication for synergistic effect. Instead, the point which should be taken into consideration is the amount and duration of intake of Benzodiazepine that is Etizolam previously. Presently, you are on Clonax (Clonazepam) and that too should be titrated accordingly. One more thing that I want to comment here is your weight. We should have a holistic approach and non-pharmacological methods are equally important to maintain weight.