HomeAnswersObstetrics and Gynecologypapp-a (PREGNANCY-ASSOCIATED PLASMA PROTEIN-A)

What does low PAPP-A and high hCG levels indicate?

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Patient's Query

Hi doctor,

My wife has done a PAPP-A screen test and results are 1.9 and hCG level 65.6. She is 12 weeks pregnant. Please advise regarding the same. Thank you.
Answered by Dr. Sameer Kumar

Education:

MBBS

Professional Bio:

Dr. Sameer Kumar is a highly qualified Obstetrician and Gynecologist and Infertility specialist with more than two decades of clinical experience. He has completed his postgraduate training in Obstetrics and Gynecology and also specializes in infertility management. Dr. Kumar is dedicated to women’s health, offering expert care in pregnancy, reproductive health, and fertility treatments. His patient-centered approach combines medical expertise with compassionate support to ensure the best outcomes for his patients. Note: If you don't want go opt for IVF and spend lakhs, then you must contact me as i specialize in medical infertility treatment for both male and female. Results have been really encouraging and statistics speak for itself, about 2000 couples helped and avoided IVF.

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Hello,

Welcome to icliniq.com.

You need to attach the complete report issued by the laboratory. Important thing is the graph and the MoM (multiple of the median) values which have been calculated as per the gestational age. The risk is calculated accordingly. In case of Down's syndrome, there is low PAPP-A (pregnancy-associated plasma protein A) levels and high hCG (human chorionic gonadotropin) levels which is what it looks like with the information provided. So please upload the scanned report completely for better review.

Patient's Query

Hi doctor,

I have attached the files for your reference. Please have a look.

Answered by Dr. Sameer Kumar

Education:

MBBS

Professional Bio:

Dr. Sameer Kumar is a highly qualified Obstetrician and Gynecologist and Infertility specialist with more than two decades of clinical experience. He has completed his postgraduate training in Obstetrics and Gynecology and also specializes in infertility management. Dr. Kumar is dedicated to women’s health, offering expert care in pregnancy, reproductive health, and fertility treatments. His patient-centered approach combines medical expertise with compassionate support to ensure the best outcomes for his patients. Note: If you don't want go opt for IVF and spend lakhs, then you must contact me as i specialize in medical infertility treatment for both male and female. Results have been really encouraging and statistics speak for itself, about 2000 couples helped and avoided IVF.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Hello,

Welcome back to icliniq.com.

As suspected there is a high risk for trisomy 21 or Down's syndrome in the fetus as per the reports (attachments removed to protect patient identity). Next best way to confirm or rule it out would be to perform karyotyping of fetal cells obtained through amniocentesis procedure by 13-15 weeks of gestation. So, please opt for it and if the karyotyping by FISH (fluorescence in situ hybridization) indicates trisomy then it shall confirm that the fetus is Down's syndrome and then the decision shall be yours to continue or terminate before 20 weeks.

Medically reviewed by iCliniq medical review team
Published At April 1, 2016
Reviewed At April 25, 2024

Education:

MBBS

Professional Bio:

Dr. Sameer Kumar is a highly qualified Obstetrician and Gynecologist and Infertility specialist with more than two decades of clinical experience. He has completed his postgraduate training in Obstetrics and Gynecology and also specializes in infertility management. Dr. Kumar is dedicated to women’s health, offering expert care in pregnancy, reproductive health, and fertility treatments. His patient-centered approach combines medical expertise with compassionate support to ensure the best outcomes for his patients. Note: If you don't want go opt for IVF and spend lakhs, then you must contact me as i specialize in medical infertility treatment for both male and female. Results have been really encouraging and statistics speak for itself, about 2000 couples helped and avoided IVF.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

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Decision Helper
PAPP-A and hCG Down Syndrome Risk Decision Helper

Concerned about your PAPP-A and hCG results?

This tool helps you understand the implications of your PAPP-A and hCG screening results and when to discuss them with a doctor.

For guidance only, not a diagnosis. Medications should be taken after consulting a physician. The dosages will be prescribed by the physician. Do not alter, start, or stop medications without consulting a healthcare professional.
Dr. Sameer Kumar
Dr. Sameer Kumar

Obstetrics and Gynecology

Education:

MBBS

Professional Bio:

Dr. Sameer Kumar is a highly qualified Obstetrician and Gynecologist and Infertility specialist with more than two decades of clinical experience. He has completed his postgraduate training in Obstetrics and Gynecology and also specializes in infertility management. Dr. Kumar is dedicated to women’s health, offering expert care in pregnancy, reproductive health, and fertility treatments. His patient-centered approach combines medical expertise with compassionate support to ensure the best outcomes for his patients. Note: If you don't want go opt for IVF and spend lakhs, then you must contact me as i specialize in medical infertility treatment for both male and female. Results have been really encouraging and statistics speak for itself, about 2000 couples helped and avoided IVF.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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