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Can I substitute Amaryl tablet with Kombiglyze tablet?

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Patient's Query

Hello doctor,

I am currently on Amaryl 2 mg. As I will be traveling shortly, to a country where I am told Amaryl is not available, but Kombiglyze is available there. Is it okay to take this substitute?
Answered by Dr. Sreejith. M. G

Education:

MD

Professional Bio:

Dr. Sreejith M. G is a General Practitioner specializing in Internal Medicine and Diabetology, with expertise in managing diabetes, hypertension, thyroid disorders, metabolic syndrome, preventive health care, and chronic disease management.

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Hi,

Welcome to icliniq.com.

Amaryl has Metformin 500 mg and Glimepiride 2 mg and Kombiglyze contains Metformin and Saxagliptin. Both combinations are different, so the level of sugar control will be different. Glimepiride is a sulfonylurea and Saxagliptin is a DPP4 (Dipeptidyl peptidase 4) inhibitor, but both are good. So, you can ask for Metformin and Glimepiride combination in that country, it will be available, but with a different company. If it is not available, you can take Kombiglyze XR also, but you have to check the blood sugar frequently and adjust the dose.

Medically reviewed by Dr. K. Shobana
Published At April 8, 2017
Reviewed At July 8, 2025

Education:

MD

Professional Bio:

Dr. Sreejith M. G is a General Practitioner specializing in Internal Medicine and Diabetology, with expertise in managing diabetes, hypertension, thyroid disorders, metabolic syndrome, preventive health care, and chronic disease management.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

Education:

BDS

Professional Bio:

Dr. K. Shobana is a Dental Surgeon specializing in oral health and dental care. She is skilled in preventive dentistry and provides oral hygiene education. She can do restorative treatments such as fillings and crowns. She can handle periodontal problems such as gum diseases and periodontitis. She can do root canal treatment.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality

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Dr. Sreejith. M. G
Dr. Sreejith. M. G

Diabetology

Education:

MD

Professional Bio:

Dr. Sreejith M. G is a General Practitioner specializing in Internal Medicine and Diabetology, with expertise in managing diabetes, hypertension, thyroid disorders, metabolic syndrome, preventive health care, and chronic disease management.

This doctor is not available for online consultations on the platform anymore.

Consult other doctors in the same speciality
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