I am getting chest pain with tightness and shortness of breath while lifting heavyweight. Why?

Hello,

Welcome to icliniq.com.

Normally, RNP (ribonuclear protein) levels below 20 units on ELISA are negative. But if it is more than 26 units, suggest positive. It suggests multiple connective tissue disorders like myositis, scleroderma, rheumatoid arthritis, etc.

PM-scl also suggests scleromyositis. Signs may present like Raynaud's phenomenon, arthritis, myositis, and scleroderma. It may present as upper limb bluish discoloration on cold exposure, multiple joint pains, early morning stiffness, fever, muscle pain, dryness of the skin, and even chest muscle spasm.

So your remaining reports appear normal only (attachment removed to protect patient identity).

It may be non-cardiac pain and look like muscular pain. But you may also get it done with serum CPK (creatinine phosphokinase) levels, blood urea, serum creatinine, and, if necessary, muscle biopsy.

If it is treated with NSAIDs (nonsteroidal anti-inflammatory drugs) like Ibuprofen and Indomethacin, it is muscular pain. If it is confirmed as MCTD (mixed connective tissue disease), then it needs to be treated with steroids and anti-metabolites.

I hope this helps.

Thank you.

Hello,

Welcome back to icliniq.com.

Yes, usually, they may be false positives also why because the chances of U1 RNP being positive in SLE (systemic lupus erythematosus), rheumatoid arthritis, scleroderma, and Raynaud's phenomenon.

But in your case, all are negative, so more chances of a false positive. In pregnancy, immunocompromised status patients may also present with false-positive results.

But we have to consider the symptoms of the patient with the remaining investigation together, then we will treat it. That is why I advised ESR (erythrocyte sedimentation rate), CRP (C-reactive protein), and a muscle biopsy to confirm whether there is any inflammation in your body or muscle.

I hope this helps.

Thank you.