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Why might CEA values increase during chemotherapy?

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Patient's Query

Hello doctor,

On chemotherapy, CEA is rising. The patient had colon cancer surgery last year and was in the third stage. A PET scan showed one metastasis in the liver of 16 mm and one distant node. The chemotheraphy was started last year. CEA is rising instead of decreasing. The CEA values were 9.8, 8, 9, 10 in the consecutive months. What happens if chemotherpay does not work?

Answered by Dr. Jaydeep Tripathy

Education:

MBBS

Professional Bio:

Dr. Jaydeep Tripathy is a dedicated General Practitioner and an expertise in mater of public health committed to compassionate, individualized care. He excels at accurate clinical diagnosis, preventive health strategies, and effective management of chronic conditions such as hypertension and diabetes. He prioritizes clear communication and trust‑based patient relationships, ensuring continuity of care across diverse populations. 

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

Stage III colon cancer will have elevated CEA (carcinoembryonic antigen) levels. However, following surgery and on chemotherapy, it should gradually come down. 10 is not very high. Still, post-surgery the standards should have been around six. Now since it is increasing, some other causes of rising CEA such as hepatitis, and peptic ulcer disease, or diverticulitis needs to be ruled out. If all these causes are ruled out, then in all probability there is a recurrence of cancer. So once again, MRI needs to be done to check for recurrence. It can happen in the failure of chemotherapy. Feel free to discuss further,

Medically reviewed by Dr. Nithila. A
Published At September 29, 2019
Reviewed At June 18, 2026

Education:

MBBS

Professional Bio:

Dr. Jaydeep Tripathy is a dedicated General Practitioner and an expertise in mater of public health committed to compassionate, individualized care. He excels at accurate clinical diagnosis, preventive health strategies, and effective management of chronic conditions such as hypertension and diabetes. He prioritizes clear communication and trust‑based patient relationships, ensuring continuity of care across diverse populations. 

This doctor is not available for online consultations on the platform anymore.

Education:

BDS

Professional Bio:

Dr. Nithila A is a Dental Surgeon specializing in providing comprehensive oral healthcare. She focuses on preventive care, routine dental treatments, and patient education to maintain optimal oral health. Known for her compassionate and patient-centered approach, she ensures comfortable and effective dental care tailored to the individual needs of each patient.

This doctor is not available for online consultations on the platform anymore.

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Education:

MBBS

Professional Bio:

Dr. Jaydeep Tripathy is a dedicated General Practitioner and an expertise in mater of public health committed to compassionate, individualized care. He excels at accurate clinical diagnosis, preventive health strategies, and effective management of chronic conditions such as hypertension and diabetes. He prioritizes clear communication and trust‑based patient relationships, ensuring continuity of care across diverse populations. 

This doctor is not available for online consultations on the platform anymore.

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