What are the treatments to manage asthma besides inhalers?

Question

Hello doctor,

I am struggling with severe asthma despite using the maximum inhaler doses. I am 39, and my pulmonologist suggested Tezspire, but I feel overwhelmed with questions. I am currently on high-dose steroids and experiencing exacerbations every few weeks. I had to visit the ER twice last month. My insurance finally approved it, but I am nervous about self-injection and potential side effects. How long might it take to see results? Will this replace my current inhalers? I really need something that works.

Please advise.

Answer 1

Hello,

Welcome to icliniq.com.

I understand your concern.

Tezspire (Tezepelumab) is a monoclonal antibody that targets thymic stromal lymphopoietin (TSLP), a key driver of inflammation in asthma. It is approved for the treatment of severe asthma. Tezepelumab offers several advantages over regular biologics based on clinical trials, including:

Improved lung function: It has been shown to enhance lung function, reducing asthma symptoms and exacerbations.
Reduced exacerbations: Studies have demonstrated a significant decrease in severe asthma exacerbations with Tezspire treatment.
Broader patient eligibility: Unlike some biologics, Tezspire is not restricted to specific biomarkers or phenotypes, making it a viable option for a wider range of patients.

As with any medication, Tezspire carries potential risks and side effects, including:

Allergic reactions: Rare but potentially severe allergic reactions can occur.
Increased risk of parasitic infections: There is a potential risk of parasitic infections, such as strongyloidiasis.
Common side effects: These may include headache, fatigue, and injection site reactions, as reported in clinical trials.

Tezspire has demonstrated effectiveness in patients with:

Uncontrolled symptoms: Significant improvements in symptoms and overall quality of life.
Frequent exacerbations: Studies show a marked reduction in severe asthma attacks.

To optimize asthma control, consider the following:

Medical reports: Please share recent pulmonary function test (PFT) reports, allergy test results, and any other relevant medical records.
Regular pulmonary function tests (PFTs): Ongoing monitoring will help assess lung function and adjust treatment as needed.
Inhaler technique and adherence: Ensure proper inhaler usage and compliance with medication. Using a spacer device or an inhaler with a built-in counter may be beneficial.
Blood tests: CBC (complete blood count), ESR (erythrocyte sedimentation rate), and IgE (immunoglobulin E) levels should be checked for further evaluation.

Tezspire is an add-on therapy and will not replace inhalers. However, the required inhaler dose may change over time. Oral steroid use is expected to significantly decrease with Tezspire treatment. Please share your reports and schedule a follow-up for further discussion.

I hope this helps clarify your concerns.

Thank you.