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Do antihistamines cause vasoconstriction as a side effect?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am experiencing significant vasoconstriction issues. I would like to know if my daily intake of antihistamines could be causing this problem. I take Loratadine and Fexofenadine hydrochloride daily for allergies.

Please suggest.

Answered by Dr. Naval Mendiratta

Hello,

Welcome to icliniq.com.

I can understand your concern.

I would like to understand in detail what you mean by vasoconstriction problems. Please answer a few questions so I can assist you better.

  1. Are you experiencing symptoms in your hands, feet, or nasal passages?
  2. Do you notice any bluish discoloration of your nails or hands?
  3. Do you have any pain in your hands or feet?
  4. Are you experiencing any ulcers?

It does not seem to be a side effect of your medications, but it might be related to your allergies. We need to identify the specific allergies you have and the associated symptoms to determine the cause of your issues.

Patient's Query

Hello doctor,

Thank you for your response.

I do not have full discoloration, but I experience lip ulcers due to vasoconstriction, constant numbness, and cold feet even in hot weather. My nipples turn bluish and are painful. I also get hives during these episodes, and my ears sometimes suddenly turn red and swell when they dilate. My face is pale, but if I massage it, it turns red, swells, becomes numb, and then returns to normal within minutes.

Additionally, I am experiencing tachycardia, palpitations, and flank pain during these episodes. Could this be related to allergies or adrenal problems?

Answered by Dr. Naval Mendiratta

Hello,

Welcome back to icliniq.com.

The persistent hives you are experiencing could be due to urticarial vasculitis along with angioedema. However, since you also have oral ulcers, it could potentially be Raynaud's disease. There might be an underlying condition that needs further investigation, possibly an autoimmune disorder.

I recommend getting the following tests done:

  1. Complement C3 and C4.
  2. ANA (antinuclear antibody).
  3. CBC (complete blood count).
  4. ESR (erythrocyte sedimentation rate).
  5. Urinalysis.

Please follow up with the results of these tests.

Answered byDr. Naval Mendiratta

Medically reviewed byDr. K. Shobana

Published At May 31, 2017
Reviewed AtOctober 14, 2025

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Naval Mendiratta
Dr. Naval Mendiratta

Rheumatology

Consult this doctor
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