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Can I take antihistamines (an OTC drug) when pregnant?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

Can I take antihistamines (an OTC drug) when pregnant?

Answered by Dr. Gowrimeena

Hi,

Welcome to icliniq.com.

Antihistamines are used to treat allergy symptoms. We have two generations of antihistamines:

First generation antihistamines like Chlorpheniramine, Dimenhydrinate, Diphenhydramine, Doxylamine are considered safe to use during pregnancy. These medications have a sedative effect (cause sleepiness).

The newer non-sedating antihistamines like Cetirizine, Desloratadine, Fexofenadine, and Loratadine are best avoided in pregnancy as we have no strong evidence confirming its safety in pregnancy.

Hope this helps.

Consult a general medicine physician online for further queries.
Answered byDr. Gowrimeena
Medically reviewed byiCliniq medical review team
Published At October 16, 2014
Reviewed AtMay 6, 2025

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Companion

Antihistamines in Pregnancy Companion

How it works

Antihistamines are common over-the-counter medications used to treat allergy symptoms. When you are pregnant, it is important to know which types are generally considered safe.

1

Antihistamines
Detail

2

First-Gen
Safety

3

Common
Types

4

Second-Gen
Avoidance

5

Newer
Types

6

Important
Considerations

This information is based on general medical guidance. It is not a substitute for professional medical advice; consult a qualified clinician.

Always consult a doctor before taking medication; self-medication carries serious health risks. Take exact prescribed doses, and never start, change, or stop treatment without medical supervision.
Dr. Gowrimeena
Dr. Gowrimeena

Obstetrics and Gynecology

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