How can a patient with pericarditis overcome the stomach pain after taking the tablet Colchicine?

Hello,

Welcome to icliniq.com.

I completely understand your concern and will try to help you out.

Gastrointestinal disorders are usually the most common adverse reactions from the tablet Colchicine. They are often the first signs of toxicity and may indicate that the Colchicine dose needs to be reduced or stopped. Colchicine affects cell division and the multiorgan system. Stomach lining epithelial cell turnover is also affected, and Rabeprazole or Ranitidine may not work as they have a different mechanism of action. First of all, to assess the extent of Colchicine toxicity, renal function tests and a hemogram should be done. You have been taking Colchicine for one year. Usually, the course should be continued for three months in acute pericarditis and six months in recurrent pericarditis. Longer durations are required only if you are symptomatic.

Hello,

Welcome back to icliniq.com.

I suggest you continue taking PPI (proton pump inhibitor) on an empty stomach before breakfast (consult a specialist doctor, discuss with them, and take medications with their consent). This is because PPI inhibits the inactivated proton pumps in the parietal cells of the stomach. The proton pumps get activated on food consumption and are unaffected by PPI. In addition, you can also take antacids which work by neutralizing the already formed acid. Avoid tea, coffee, and carbonated drinks. Try drinking some alkaline water with a pH of more than 8.5 regularly.