HomeAnswersEndocrinologyaddison's disease

What are the diagnostic tests for Addison's disease?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I am positive for 21 hydroxylase antibodies and was wondering if this is enough evidence to prove Addison's illness. I am currently taking Viibryd 20 mg and had a vein puncture test recently.

Kindly help.

Answered by Dr. Shaikh Sadaf

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology. She completed her MBBS from the University of Pune, MRCPI Internal Medicine from Ireland, MRCGP (Membership of the Royal College of General Practitioners) [INT] from Royal College of General Practitioners, UK. She has 20 years of clinical experience and currently practicing in UK.

This doctor is not available for online consultations on the platform anymore.

Hello,

Welcome to icliniq.com.

Positive 21-hydroxylase antibody titers are both sensitive (about 90 %) and specific (>99 %) for autoimmune adrenalitis. Positive antibodies to 21-hydroxylase confirm an autoimmune adrenal insufficiency etiology. Additionally, blood calcium, phosphorus, fasting glucose, free thyroxine (T4), and thyroid-stimulating hormone (TSH) levels are tested to rule out concomitant autoimmune hypoparathyroidism, diabetes, and hypothyroidism. If hypocalcemia is discovered, the amount of serum parathyroid hormone should be determined. Serum follicle-stimulating hormone, luteinizing hormone, and estradiol levels must also be measured. Then an abdominal CT (computed tomography) is required to detect adrenal gland hypertrophy. These are the basic tests required to diagnose autoimmune adrenal insufficiency.

Medically reviewed by iCliniq medical review team
Published At January 4, 2024
Reviewed At January 4, 2024

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology. She completed her MBBS from the University of Pune, MRCPI Internal Medicine from Ireland, MRCGP (Membership of the Royal College of General Practitioners) [INT] from Royal College of General Practitioners, UK. She has 20 years of clinical experience and currently practicing in UK.

This doctor is not available for online consultations on the platform anymore.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Education:

MBBS

Professional Bio:

Dr. Shaikh Sadaf is a Specialist in Diabetology and Endocrinology. She completed her MBBS from the University of Pune, MRCPI Internal Medicine from Ireland, MRCGP (Membership of the Royal College of General Practitioners) [INT] from Royal College of General Practitioners, UK. She has 20 years of clinical experience and currently practicing in UK.

This doctor is not available for online consultations on the platform anymore.

Listen to related tracks in our music library
Comprehensive Second Opinion

Read answers about:

hypoparathyroidismtyrosine hydroxylase deficiencyaddison's disease

Ask your health query to a doctor online

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.