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Tuberculosis in Infants: A Comprehensive Guide to Diagnosis and Treatment

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Tuberculosis is the most common disease caused by a significant population. The bacteria called Mycobacterium tuberculosis causes the infection.

Medically reviewed by

Dr. Veerabhadrudu Kuncham

Published At October 18, 2023
Reviewed AtOctober 18, 2023

Introduction

Tuberculosis, commonly known as TB, is a contagious bacterial infection that primarily affects the lungs but can also impact other parts of the body. While TB is often associated with adults, it can also affect infants, posing unique challenges in diagnosis and treatment. Tuberculosis in infants requires special attention and care due to their delicate immune systems and limited ability to communicate symptoms. Unlike adults, infants may not exhibit the classic symptoms of TB, such as persistent cough or weight loss. The manifestations of tuberculosis in infants can be subtle and easily mistaken for other common childhood illnesses. This makes early detection and accurate diagnosis crucial for effective management and prevention of complications.

This article will explore the various aspects of tuberculosis in infants, including its causes, symptoms, diagnostic methods, and available treatment options. It will delve into the unique considerations that healthcare providers and parents need to keep in mind when dealing with TB in this vulnerable population.

What Is Tuberculosis in Infants?

Tuberculosis is the most common infection caused by the bacteria called Mycobacterium tuberculosis. Usually, the lungs are infected by the bacteria, but in rare conditions, the other organs are affected by the disorder. Droplets of the infected person mainly transmit tuberculosis cough into the air. The bacteria also infect children.

What Are the Stages of Tuberculosis?

There are three stages of tuberculosis:

  • Exposure.

  • Latent TB infection.

  • Tuberculosis disease.

1. Exposure Stage: This is the initial stage where the child is directly exposed to the droplets of an infected person. But children under 12 years of age rarely infect the other person primarily, and adults cause the transmission. At this stage, the child will show negative on the skin test, does not show any symptoms, and chest X-rays show normal.

2. Latent Tuberculosis Infection: This is the stage when the infection enters the body. The children do not exhibit symptoms, but X-ray findings are normal. An infected person does not spread the disease to others. Instead, the bacteria enter the child, and the child's immune system fights against the bacteria.

3. Tuberculosis Disease: This is the final stage where the individual exhibits symptoms. Here the infected person can spread the disease. In this stage, the skin test is positive, can see the X-ray findings, and extends the condition.

What Causes Tuberculosis?

Tuberculosis is a bacterial infection caused by Mycobacterium tuberculosis. The bacteria are spread from the infected person to the average person. The disease spreads through droplets and mucus secretions when the infected person sneezes, coughs, or talks.

What Are the Symptoms of Tuberculosis?

One of the good things about tuberculosis is that most individuals, either children or adults, who are exposed to the infection, do not show any symptoms. This is because when the bacteria reach the lungs, the body's immune system starts attacking the bacteria and germs and prevents further disease infection. Even if the child does not show any symptoms, it is crucial to start the treatment immediately to reduce the risk of future progression of the infection.

Very rarely, a small group of infected individuals, like children or adults, or teens, show few symptoms such as fever, severe cough, sneezing, weakness, night sweats, irritability, fatigue, weight loss, poor growth, swollen glands, and palpitations. Anyone with weaker immunity, whether kids under four years of age, teens, or older, may show the symptoms, and the body cannot fight against the germs. The bacteria spread in the bloodstream causing various infections.

Other symptoms include:

  • Cough that lasts for more than three weeks.

  • Chest pain.

  • Blood in the sputum.

  • Weakness.

  • Tiredness.

  • Loss of appetite.

  • Fever with chills.

Who Is at High Risk of Tuberculosis?

The following children are at higher risk of tuberculosis. Usually, children with weaker are at increased risk:

  • HIV (human immunodeficiency virus).

  • Diabetes.

  • Few children treated with any condition that weakens their immunity are at higher risk of tuberculosis infection.

  • Weaker immunity.

  • Cancer therapies.

  • If someone is at home with tuberculosis infection.

  • Homeless people.

  • Lives in a country where tuberculosis infections are common.

How Is Tuberculosis Diagnosed?

A health care provider may do a complete examination and ask for their family history of tuberculosis infection. Check for the symptoms. If the doctor suspects tuberculosis, he first conducts a small skin test. In the skin test, a small amount of solution is injected superficially into the skin. Then after injecting the solution into the skin, if there is any bump on the skin after two to three days, the person is positive for the skin test. The doctor may also perform a chest X-ray. A sputum test is also done to diagnose tuberculosis infection in children. Finally, a blood test called interferon-gamma release assay is done to confirm the diagnosis. The skin test is also advised for people who are having:

  • HIV.

  • X-ray that looks like tuberculosis.

  • A person from a country where TB is common.

  • Any family history of tuberculosis.

How Is Tuberculosis Treated?

The treatment options may vary from person to person, depending on the severity of the symptoms.

  • The child may need short-term hospitalization.

  • The person may require six to 12 months of medications for latent tuberculosis.

  • Individuals with active tuberculosis require three to four medicines for about six months or more.

  • Talk to a child's pediatrician about the risks and benefits of the medications.

  • Complete the course of medications as prescribed by the doctor.

  • Keep an eye on the child's health condition and monitor the symptoms regularly to avoid further disease complications.

Conclusion

Tuberculosis is the most common disease caused by a significant population. The bacteria called Mycobacterium tuberculosis causes the infection. Usually, the lungs are infected by the bacteria, but in rare conditions, the other organs are affected by the disorder. Droplets of the infected person mainly transmit tuberculosis coughs into the air. The bacteria also infect children. Very rarely, a small group of infected individuals, like children or adults, or teens, show few symptoms such as fever, severe cough, sneezing, weakness, night sweats, irritability, fatigue, weight loss, poor growth, swollen glands, and palpitations.

Anyone with weaker immunity, whether kids under four years of age, teens, or older, may show the symptoms, and the body cannot fight against the germs. The bacteria spread in the bloodstream causing various infections.

Dr. Veerabhadrudu Kuncham
Dr. Veerabhadrudu Kuncham

Pediatrics

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