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Liver Involvement in Rheumatic Diseases - Symptoms, Diagnosis, Treatment, and Prevention

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This article examines liver involvement in rheumatic diseases, including symptoms, diagnosis treatment, and emphasizes the importance of liver care.

Written by

Dr. Vandana Rai

Medically reviewed by

Dr. Kaushal Bhavsar

Published At August 11, 2023
Reviewed AtSeptember 8, 2023

Introduction:

Rheumatic diseases comprise a range of autoimmune disorders characterized by inflammation and pain affecting the joints, muscles, and other connective tissues. While the primary symptoms of rheumatic diseases are related to the musculoskeletal system, these conditions can also affect other organs in the body, including the liver. Maintaining a healthy liver is crucial for our overall well-being.

Why Is the Liver Important?

The liver is responsible for numerous vital bodily functions, such as producing bile, which helps digest fats; filtering out toxins from the blood; storing glucose for energy; and producing proteins for blood clotting. A healthy liver is necessary for the proper functioning of our body.

How Do Rheumatic Diseases Affect the Liver?

Rheumatic diseases can cause liver damage in several ways. Some types of rheumatic diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), can cause inflammation in the liver, leading to liver injury and scarring. Additionally, certain medications used to treat rheumatic diseases can be hepatotoxic, meaning they can cause liver damage.

What Are the Symptoms of Liver Involvement in Rheumatic Diseases?

The symptoms of liver involvement in rheumatic diseases can vary based on the specific condition and the extent of liver damage. Some common symptoms include:

  • Jaundice (yellowing of the skin and eyes).
  • Abdominal pain and swelling.
  • Fatigue.
  • Nausea and vomiting.
  • Loss of appetite.
  • Dark urine.
  • Pale stools.

How Is Liver Involvement in Rheumatic Diseases Diagnosed?

Diagnosing liver involvement in rheumatic diseases typically involves a combination of blood tests, imaging studies, such as ultrasound or CT (computed tomography) scan, and liver biopsy. Blood tests can help identify liver enzyme levels and other markers of liver function. At the same time, imaging studies can provide a visual picture of the liver and any damage that may be present. A liver biopsy involves extracting a small sample of liver tissue for microscopic examination, allowing for an assessment of the degree of damage present.

How Can Liver Involvement in Rheumatic Diseases Be Prevented?

Preventing liver involvement in rheumatic diseases may not always be possible, as underlying autoimmune disorders often cause these conditions. However, some steps can be taken to minimize the risk of liver damage. For example, it is important to monitor liver function regularly with blood tests and imaging studies, particularly if taking medications that can be hepatotoxic. Maintaining a healthy lifestyle, such as eating a balanced diet and exercising regularly, can also help prevent liver damage. Additionally, avoiding alcohol and other substances known to be harmful to the liver can help protect against liver damage in people with rheumatic diseases.

Specific medications can be hepatotoxic and should be monitored closely. Certain supplements or herbs help protect against liver damage. These are all critical topics to discuss with your doctor if someone has rheumatic disease and is concerned about liver involvement. It is also essential to follow your doctor's recommendations for managing your condition and promptly report any new symptoms or concerns.

How Is Liver Involvement in Rheumatic Diseases Treated?

Treatment approaches for liver involvement in rheumatic disease differ based on the specific condition and severity of liver damage. Here are some common treatment strategies:

  1. Medications: In many cases, medications are used to manage the underlying rheumatic disease and reduce inflammation, which can help alleviate liver involvement. Nonsteroidal anti-inflammatory drugs (NSAIDs), Corticosteroids, disease-modifying antirheumatic drugs (DMARDs), and biologic agents may be prescribed by a rheumatologist.
  2. Immunosuppressive Therapy: For more severe liver involvement, immunosuppressive medications may be used to suppress the immune system and reduce inflammation. These medications, such as Azathioprine, Methotrexate, or Mycophenolate mofetil, can help prevent further damage to the liver.
  3. Antiviral Therapy: If liver involvement is due to a viral infection, such as hepatitis B or C, antiviral medications may be prescribed. These medications target the specific virus and help control the infection, reducing liver inflammation and preventing further damage.
  4. Liver-specific Treatments: Specific treatments targeting liver function may be necessary in advanced liver damage or cirrhosis (chronic liver disease) cases. This can include interventions such as liver transplantation or surgical procedures to address complications like portal hypertension or liver cancer.

How Can Lifestyle Choices and Precautions Help in Taking Care of the Liver?

part from the tips mentioned earlier, one can do a few other things to care for the liver:

  1. Avoid exposure to toxins and chemicals that can damage your liver. This includes avoiding smoking, drug abuse, and exposure to harmful chemicals at work.
  2. Vaccinate for hepatitis A and B, as these viruses can cause liver damage.
  3. Avoid taking unnecessary medications, especially if you already have liver disease. Some medications can harm the liver, so always consult your doctor before taking any medication.
  4. Get regular check-ups with your healthcare provider to monitor your liver health.

The doctor can perform tests to check for liver damage and advise on maintaining a healthy liver.

What Are the Additional Lifestyle Changes to Reduce the Risk of Liver Damage?

In addition to monitoring medication use and considering alternative treatments, lifestyle changes can help prevent liver damage in people with rheumatic diseases. Here are some examples:

  • Avoid Alcohol: Consuming alcohol can strain the liver and increase the risk of liver damage. Restricting alcohol consumption or abstaining from it entirely, if feasible, is crucial for maintaining optimal health.
  • Maintain a Healthy Weight: Being overweight or obese can also contribute to liver damage. Promoting a healthy weight and reducing the likelihood of liver damage can be facilitated by embracing a nourishing diet and integrating consistent physical activity.
  • Practice Safe Sex: Certain sexually transmitted infections, such as hepatitis B and C, can increase the risk of liver damage. Practicing safe sex and getting tested regularly for these infections can help prevent liver damage.
  • Manage Chronic Conditions: People with rheumatic diseases often have other chronic conditions, such as diabetes or high blood pressure, which can also increase the risk of liver damage. Managing these conditions through medication, lifestyle changes, and regular check-ups can help prevent liver damage.

By incorporating these lifestyle changes, monitoring medication use, and considering alternative treatments, people with rheumatic diseases can take a comprehensive approach to preventing liver damage and maintaining optimal health.

Conclusion:

Liver involvement in rheumatic diseases is a serious complication that can cause significant health problems. If someone has a rheumatic disease, it is important to speak with the doctor about monitoring their liver function and addressing any symptoms of liver damage as soon as possible. Proper management can minimize liver damage associated with rheumatic diseases, improving overall health outcomes.

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Dr. Kaushal Bhavsar
Dr. Kaushal Bhavsar

Pulmonology (Asthma Doctors)

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